CD(分化抗原簇)

CD类别、分布、所属家族以及作用

Human leukocyte differentiation antigens

CD no.SessionMain antigen expressionFamily
CD1aTCortical mature thymocytes, dendritic cell subset, Langerhans cellsIgSF
CD1bTCortical mature thymocytes, dendritic cell subset, Langerhans cells
CD1cTCortical mature thymocytes, dendritic cell subset, Langerhans cells, B cell subset
CD1dTCortical thymocytes, dendritic cell subset, Langerhans cells, intestinal epithelium
CD1eTCortical thymocytes, dendritic cell subset
CD2TThymocytes, T cells, most NK cells, B cellsIgSF
CD2RTActivated T cells, NK cells
CD3dTT cellsT cell receptor complex
CD3eTT cells
CD3gTT cells
CD3zNT cells, NK cells, macrophagesND
CD4THelper/inducer T cells, monocyte subset, thymocyte subset, macrophagesIgSF
CD5TMature T cells, thymocytes, B cell subsetSRCR
CD6TMature T cells, B cell subset, medullary thymocytesSRCR
CD7TMature T cells, NK cells, immature myeloid cell subsetIgSF
CD8aTCytotoxic/suppressor T cells, NK cell subset, thymocytesT cell coreceptor
CD8bTCytotoxic/suppressor T cells, NK cell subset, thymocytes
CD9PPlatelets, activated T cells, eosinophils, basophils, endothelial cells, pre-B cellsTM4SF
CD10BPre-B cell subset, B cell subset, cortical thymocyte subset, granulocytes, monocyte subsetZinc metalloprotease
CD11aAdMost of lymphoid and myeloid cellsIntegrin a chain
CD11bAdMyeloid cells and NK cellsIntegrin a chain
CD11cAdMyeloid cells, NK cells macrophages, activated T cellsIntegrin a chain
CD11dAdLeucocytesIntegrin a chain
CDw12MMonocytes, granulocytes, platelets, NK cells
CD13MMonocytes, neutrophils
CD14MMonocytes, macrophages, Langerhans cellsLRG
CD15AdNeutrophils, eosinophils, monocytes, Reed Sternberg cellsCarbohydrate 2
CD15sAdNeutrophils, basophils, monocytesSialylated carbohydrate 2
CD15uCa
CD16aNNK cells, macrophages, mast cells, monocytesIgSF
CD16bNGranulocytes neutrophil onlyIgSF
CDw17MNeutrophils, basophils, monocytes, platelets, B cell subsetLacCer
CD18AdLeucocytesIntegrin
CD19BPrecursor B cells and B cells, follicular dendritic cellsIgSF
CD20BPrecursor B cell subset, B cellsCD20 family
CD21BMature B cells, follicular dendritic cells, thymocyte subsetRCA
CD22BPrecursor and mature B cellsIgSF
CD23BB cells, monocytes, follicular dendritic cellsC-type lectin
CD24BB cells, granulocytesCD52/CD24/HSA
CD25CkActivated T and B cells, stimulated monocytes/macrophages
CD26XMature thymocytes, activated T cells, B cells, macrophages, NK cellsSerine-type exopeptidase
CD27TMature T cells, B cell subset, NK cellsTNF receptor family
CD28TMature thymocytes subset, T cells, plasma cellsIgSF
CD29AdBroadIntegrin
CD30XActivated T and B cells, activated NK cells, monocytes, Reed Sternberg cellsTNF receptor family
CD31AdPlatelets, endothelial cells, monocytes, NK cells, neutrophils, T cell subsetIgSF
CD32MBroad except NK cellsFc receptor
CD33MPan myeloid, majority of monocytic cellsSialoadhesin family,IgSF
CD34MHematopoietic precursor cells, endothelial cellsSialomucin
CD35MNeutrophils, eosinophils, monocytes, follicular dendritic cells, B cells, erythrocytes, T cell subset RCA
CD36PPlatelets, monocytes, macrophages, early erythroid cells, endothelial cells
CD37BB cells, weak on T cells, monocytes, granulocytesTetraspan
CD38BPlasma cells, majority of hemopoietic cellsADP-ribosyl cyclase
CD39BMantle zone B cells, activated T cells, NK cells, dendritic cells, Langerhans cells, monocytesEcto-apyrase
CD40BB cells, macrophages, follicular dendritic cells, endothelial cells, plateletsTNF/NGF receptor
CD41PPlatelets and platelet precursorsIntegrin
CD42aPPlatelets, megakaryocytesLGR
CD42bPPlatelets, megakaryocytesLGR
CD42cPPlatelets, megakaryocytesLGR
CD42dPPlatelets, megakaryocytesLGR
CD43XBroad, except resting B cellsSialomucin
CD44 and CD44SAdMost cell typesHyaladherin
CD44RAdEpithelial cells, monocytic cells
CD45XAll hematopoietic cellsPTPase
CD45RAXNaive resting T cells, medullary thymocytes
CD45RBX
CD45RCX
CD45ROXMemory-activated T cells, cortical thymocytes
CD46XBroadRCA
CD47AdBroadIgSF
CD47RXBroad
CD48XPan leukocyteIgSF
CD49aAdActivated T cells, monocytes, NK cells, endothelial cellsIntegrin
CD49bAdPlatelets, megakaryocytes, NK cells, endothelial cellsIntegrin
CD49cAdNon-hematopoietic cellsIntegrin
CD49dAdBroadIntegrin
CD49eAdBroadIntegrin
CD49fAdBroad (except erythrocytes)Integrin
CD50AdLeukocytes, endothelial cells, epidermal Langerhans cellsIgSF
CD51PPlatelets, endothelial cells, activated T cells, B cell subsetIntegrin
CD52XThymocytes, lymphocytes, monocytes, macrophagesCD52/CD24/HSA
CD53XPan leukocyteTM4SF
CD54AdActivated endothelial cells, activated T and B cells, monocytesIgSF
CD55XBroadRCA
CD56NNK cells, T cell subsetIgSF
CD57NNK cell subset, T cell subset
CD58AdBroadIgSF
CD59XBroadLy6
CD60aCaT cell subset, plateletsGlycolipid
CD60bCaGlycolipid
CD60cCaGlycolipid
CD61PPlatelets, megakaryocytesIntegrin
CD62EAdEndothelial cellsSelectin
CD62LAdT and B cells, monocytes, granulocytes, some NK cellsSelectin
CD62PAdPlatelets, megakaryocytes, activated endothelial cellsSelectin
CD63PActivated platelets, monocytes, degranulated neutrophils, endotheliumTetraspan, TM4SF
CD64MMonocytes, macrophages, dendritic cell subsetIgSF
CD65MGranulocytes (monocytes)poly-N-acetyllactosamine
CD65sMGranulocytes, monocytespoly-N-acetyllactosamine
CD66aMGranulocytes and epithelial cellsIgSF, CEA
CD66bMGranulocytesIgSF, CEA
CD66cMGranulocytes and epithelial cellsIgSF, CEA
CD66dMGranulocytesIgSF, CEA
CD66eMEpithelial cellsIgSF, CEA
CD66fMMyeloid cell lines, fetal liver, placental syncytiotrophoblastsIgSF, CEA
CD67cancelled: now CD66b
CD68MMonocytes, macrophages, dendritic cells, neutrophils, myeloid progenitor cellsSialomucin
CD69NActivated T and B cells, thymocytes, NK cells, neutrophils, eosinophilsC-type lectin
CD70XActivated B and T cellsTNF
CD71XProliferating cells, reticulocytes, erythroid precursorsTransferrin receptor
CD72BPan B, including progenitorsC-type lectin
CD73BB and T cell subsets, follicular dendritic cells, epithelial cells, endothelial cellsGPI-anchored
CD74BB cells, activated T cells, macrophages, activated epithelial and endothelial cells
CD75CaMature B cells, T cell subsetLactosamine
CD75sCaMature B cells, T cell subsetSialylated lactosamine
CDw76cancelled: now CD75s
CD77BBurkitt's lymphoma cells, germinal center B lymphocytesCarbohydrate
CDw78cancelled
CD79aBB cellsIgSF
CD79bBB cellsIgSF
CD80BActivated B and T cells, macrophagesIgSF
CD81BBroad hemopoietic, endothelial and epithelial cellsTetraspan
CD82BBroadTetraspan
CD83BCirculating and interdigitating reticular dendritic cells, Langerhans cellsIgSF, Siglec
CD84BMature B cells, monocytes, macrophages, platelets, thymocytes and T cell subset
CD85aDMonocytes, macrophages, granulocytes, dendritic cells, T cell subsetIgSF
CD85bDMonocytes, macrophages, dendritic cellsIgSF
CD85cDIgSF
CD85dDMonocytes, macrophages, dendritic cellsIgSF
CD85eDMonocytesIgSF
CD85fDIgSF
CD85gDMonocytesIgSF
CD85hDMonocytes, dendritic cell subset, macrophages, granulocytes, NK subsetIgSF
CD85iDMonocytesIgSF
CD85jDMonocytes, macrophages, dendritic cells, NK subset, T cell subset, B cellsIgSF
CD85kDMonocytes, macrophages, dendritic cellsIgSF
CD85lDIgSF
CD85mDIgSF
CD86BMemory B cells, monocytes, dendritic cells, endothelial cells and activated T cellsIgSF
CD87MT cells, NK cells, monocytes and neutrophils as well as non-hemopoietic cellsGPI-anchored
CD88MGranulocytes, monocytes, dendritic cellsRhodopsin
CD89MMyeloid cellsIgSF, Fc receptor, MIRR
CD90EnHemopoietic stem cells, neuronsIgSF, GPI linked
CD91MMonocytes, macrophages, neurons, fibroblastsLDL receptor
CD92MMonocytes, granulocytes
CDw93MMonocytes, granulocytes, endothelial cells
CD94NNK cells, g/d and a/b T cell subsetsC-type lectin
CD95CkBroad including activated T and B cellsTNF/NGF receptor
CD96NActivated T and NK cellsIgSF
CD97XActivated T and B cells, monocytes, granulocytesEGF-TM7
CD98XBroad on activated cells
CD99TBroad, including lymphocytes
CD99RTRestricted hematopoietic expression
CD100XBroadSemaphorin
CD101MGranulocytes, monocytes, dendritic cells, activated T cellsIgSF
CD102AdResting lymphocytes, monocytes, platelets, vascular endothelial cellsIgSF
CD103AdMucosa associated T lymphocytesIntegrin
CD104AdEpithelial cells, keratinocytes, Schwann cells, monocytes, endothelial cellsIntegrin
CD105EnActivated monocytes, endothelial cells, stromal cells, pre-B cellsTGF receptor
CD106EnFollicular dendritic cells, activated endotheliumIgSF
CD107aPDegranulated platelets, activated neutrophils, activated T cells
CD107bPDegranulated platelets, activated neutrophils
CD108XErythrocytes, circulating lymphocytes
CD109CaActivated T cells and platelets, endothelial cells
CD110PHematopietic stem and progenitor cells, megakaryocytes, plateletsIgSF
CD111MCD34+ hematopoietic progenitors, epithelial and neuronal cellsIgSF
CD112MCD34+ hematopoietic progenitors, epithelial and endothelial cellsIgSF
CD113NA (reserved)
CD114MGranulocytes, monocytes, mature platelets, endothelial cellsClass I CK-R
CD115MMonocytes, macrophages and their precursors, placentaIgSF, tyrosine kinase R
CD116CkMacrophages, neutriphils, eosinophils, dendritic cells and their precursorsIgSF, class I CK-R
CD117CkHematopoietic progenitor cells, tissue mast cellsIgSF, tyrosine kinase R
CD118NA (reserved)
CDw119CkBroadIgSF, class II CK-R
CD120aCkBroadTNF receptor
CD120bCkBroadTNF receptor
CD121aCkBroadIgSF
CDw121bCkB cells, myeloid cells, some T cellsIgSF
CD122CkNK cells, T cells and B cells, monocytes/macrophagesIgSF, CK-R
CD123CkMyeloid cells including early progenitors endothelial cellsIgSF, class I CK-R
CD124CkBroadIgSF, CK-R
CDw125CkEosinophils, activated B cells, basophilsIgSF, CK-R
CD126CkT cells, monocytes, activated B cellsIgSF, class I CK-R
CD127CkT cells, B cell precursorsIgSF, CK-R
CDw128aCkNeutrophils, T cell subset, monocytes, endothelial cells, fibroblasts, plateletsChemokine receptor
CDw128bCkNeutrophils, T cell subset, monocytes, melanocytesChemokine receptor
CD129NA (reserved IL-9R)
CD130CkBroadClass I CK-R
CDw131CkMyeloid cells, early B cellsClass I CK-R
CD132CkT and B cells, NK cells, monocytes/macrophages, neutrophilsClass I CK-R
CD133SCD34+ hematopoietic progenitors, neural and endothelial stem cells5-TM
CD134CkActivated T cellsTNF/NGF receptor
CD135CkEarly and lymphoid committed progenitorsTyrosine kinase receptor
CDw136CkBroadTyrosine kinase receptor
CDw137CkT cellsTNF receptor
CD138AdPre-B cells, plasma cellsSyndecan
CD139BB cells, monocytes, granulocytes, follicular dendritic cells
CD140aEnFibroblasts, smooth muscle cells, plateletsSplit-tyrosine kinase
CD140bEnFibroblasts, smooth muscle cells, monocytes, neutrophils, endothelial cellsSplit-tyrosine kinase
CD141EnEndothelial cells, monocytes, neutrophils, megakaryocytes, plateletsC-type lectin
CD142EnEpithelial cells, stromal cells, keratinocytesSerine protease cofactor
CD143EnEndothelial and epithelial cells, activated macrophagesPeptidylpeptidase
CD144EnEndothelial cellsCadherin
CDw145EnEndothelial cells, some stromal cells
CD146EnEndothelial cells, smooth muscle cells, activated T cells, melanoma cellsIgSF
CD147EnLeukocytes, red blood cells, platelets and endothelial cellsIgSF
CD148XGranulocytes, monocytes, resting T cells, dendritic cells, platelets, fibroblastsRPTPase type III, phosphatase
CDw149cancelled: now CD47R
CD150XThymocytes, B cells, T cell subset, dendritic cells, endothelial cellsIgSF
CD151PPlatelets, megakaryocytes, endothelial and epithelial cellsTetraspan
CD152TActivated T and B cellsIgSF
CD153TActivated T cells, activated macrophages, neutrophils, B cellsTNF
CD154TActivated CD4+T cellsTNF
CD155MMonocytes, broad tissue distributionIgSF
CD156aMMonocytes, neutrophilsADAM
CD156bMBroadADAM
CD157MGranulocytes, monocytes, bone marrow stromal cellsADP-ribosyl cyclase
CD158aNNK cell subset, minor subset of T cellsIgSF
CD158b1NNK cell subset, minor subset of T cellsIgSF
CD158b2NNK cell subset, minor subset of T cellsIgSF
CD158cNNK cell subset, minor subset of T cellsIgSF
CD158dNNK cell subset, minor subset of T cellsIgSF
CD158e1NNK cell subset, minor subset of T cellsIgSF
CD158e2NNK cell subset, minor subset of T cellsIgSF
CD158fNNK cell subset, minor subset of T cellsIgSF
CD158gNNK cell subset, minor subset of T cellsIgSF
CD158hNNK cell subset, minor subset of T cellsIgSF
CD158iNNK cell subset, minor subset of T cellsIgSF
CD158jNNK cell subset, minor subset of T cellsIgSF
CD158kNNK cell subset, minor subset of T cellsIgSF
CD158zNNK cell subset, minor subset of T cellsIgSF
CD159aNNK cell subset, T cells, thymocytesC-type lectin
CD160NNK cells, cytotoxic T cellsIgSF
CD161NNK cells, T cellsC-type lectin
CD162AdMonocytes, granulocytes, T cells, some B cellsSialomucin
CD162RNNK cell subset
CD163MMonocytes, macrophagesScavenger receptor
CD164AdMonocytes, B cells (weak expression), CD34+ progenitor cells, bone marrow stromal cells, epithelial cellsSialomucin
CD165AdLymphocyte subset, monocytes, platelets, thymocytes
CD166AdActivated T cells, activated monocytes, epithelium fibroblasts, neuronsIgSF
CD167aAdEpithelial cellsKinases
CD168AdBroad
CD169AdMacrophagesIgSF
CD170AdNeutrophils, macrophages
CD171AdNeurons, some epithelial cells and some lymphoid and myelomonocytic cellsIgSF
CD172aAdStem cells, monocytes, T cell subset
CD173CaRed blood cells, platelets, CD34 stem cell subsetBlood group antigen
CD174CaEpithelial and endothelial cells, granulocytes, CD34 stem cell subsetBlood group antigen
CD175CaStem cell subset
CD175sCaErythroblasts
CD176CaStem cell subset
CD177MNeutrophil subset
CD178CkLymphoid cellsTNF
CD179aBPro-B and early pre-B cellsIgSF
CD179bBPro-B and early pre-B cellsIgSF
CD180BMantle and marginal zone B cells, monocytes, dendritic cellsToll-like receptor family
CD181-CD182NA (reserved)
CD183CkT cells, plasmacytoid dendritic cells, subsets of NK and B-cells, eosinophilsChemokine receptor
CD184CkBroad in blood and tissue cells, CD34 stem cell subsetChemokine receptor
CD185-CD194NA (reserved)
CD195CkMonocytes, T cell subset
CD196NA (reserved)
CDw197CkPeripheral T and B cells, bone marrow and cord blood CD34+ HPC, dendritic cellsChemokine receptor
CD198-CD199NA (reserved)
CD200XThymocytes, B cells, activated T cells
CD201EnEndothelial cell subsetCD1/MHC super family
CD202bEnEndothelial cells, stem cellsTyrosine kinase receptor
CD203cMBasophils, mast cellsEctoenzyme
CD204MMacrophages
CD205DDendritic cellsC-type lectin
CD206DDendritic cells, macrophagesC-type lectin
CD207DLangerhans cellsC-type lectin
CD208DInterdigitating dendritic cells, mature dendritic cellsLAMP family
CD209DDendritic cell subsetsC-type lectin
CDw210CkT and B cells, NK cells, monocytes, macrophages
CD211NA (reserved)
CD212CkActivated T cells, activated NK cells
CD213a1CkBasophils, mastocytes
CD213a2CkB cells, monocytes
CD214-CD216NA (reserved)
CDw217CkMonocytes, erythroblasts
CD218-CD219NA (reserved)
CD220XBroad
CD221XBroad
CD222XBroadLectins
CD223XActivated T cells, activated NK cells
CD224XVascular endothelium, peripheral blood macrophages, activated T cells, CD45RO+ T cells, B cell subsetMembrane-bound ectoenzyme
CD225XBroad
CD226TNK cells, platelets, monocytes, subset of T cells, thymocytesIgSF
CD227XGranular and ductal epithelial cellsMucin
CD228XMelanoma cells, progenitor cellsTransferrin family, GPI anchor
CD229XT and B cells
CD230XBroad
CD231XT cell acute lymphoblastic leukemia, neuroblastoma cellsTM4SF
CD232XBroad
CD233QErythrocyte plasma membraneBicarbonate transporter
CD234QErythroid cells, endothelial cells, some epithelial cellsChemokine receptor
CD235aQRed blood cells, erythroid precursor cells
CD235bQRed blood cells, erythroid precursor cells
CD235abQRed blood cells, erythroid precursor cells
CD236QRed blood cells, stem cell subset
CD236RQRed blood cells, stem cell subset
CD237NA (reserved)
CD238QRed blood cells, stem cell subsetNeutral endopeptidase
CD239QRed blood cells, stem cell subsetIgSF
CD240CEQRed blood cells
CD240DQRed blood cells
CD240DCEQRed blood cells
CD241QRed blood cells
CD242QErythrocytes, lymphocytesIgSF
CD243SStem cells, NK cells, T cells, Tumor cellsABC transporters
CD244NNK cells, T cell subset, monocytes, basophilsIgSF
CD245TT cell subset
CD246TAnaplastic T cell leukemia
CD247TT cells, NK cells

Session keys:Ad

AdhesionB

B cellsCa

Carbohydrates/lectinsCk

Cytokines/chemokinesD

Dendritic cellsEn

Endothelial cellsEr

Erythroid cellsM

Myeloid cellsN

NK cellsP

PlateletsS

Stem cellsT

T cellsX

Blind panel

当然这里也有简化版本的(simply simplified in text merely actually())

NameAliasFunction
CD1aR4,T6Antigen presenting protein
CD1bT6Antigen presenting protein
CD1cR7, CD1, CD1A, BDCA1Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1dR3G1Antigen presenting protein
CD2T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3RAdhesion between T-cells and other cell types and T-cell activation.
CD3dT3D, IMD19, CD3-DELTAT-cell activation signaling and regulation of TCR expression
CD3eT3E, TCRE, CD3 epsilonT-cell activation signaling and regulation of TCR expression
CD3gT3G, IMD17, CD3-GAMMAT-cell activation signaling and regulation of TCR expression
CD4T4T-cell activation, thymic differentiation and receptor for HIV
CD5T1, Tp67, LEU1Regulates T-cell receptor signaling
CD6T12, OX52, TP120T-cell activation and cell adhesion
CD7LEU 9, GP40, TP41T-cell interactions
CD8aT8, Leu-2, MAL, CD8 alphaCo-receptor for MHC class 1 molecules
CD8bCD8B1, P37Co-receptor for MHC class 1 molecules
CD9p24, MRP-1, 5H9 antigen, MIC3, TSPAN29, GIG2Platelet activation and aggregation, and cell adhesion and cell motility
CD10CALLA, NEP, gp100, Neprilysin, SFE, MME, EPNPeptidase, regulates B-cell growth
CD11aLFA-1, LFA1A, ITGALIntracellular adhesion and costimulation.
CD11bITGAM, CR3A, MO1A, MAC-1, MAC1A, SLEB6Cell adhesion, and immune response
CD11cp150, 95, CR4, integrin αX, LFA-1A, ITGAXCell adhesion
CD13Aminopeptidase N, APN, ANPEP,PEPNAminopeptidase
CD14LPS-RReceptor for complex of LPS and LBP
CD15LeX, FUT4, ELFT, FCT3A, FUTIV, SSEA-1, FUC-TIVCD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias
CD16aFcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3Low affinity Fc receptor. Mediates phagocytosis and antibody-dependent T-cell-mediated cytotoxicity
CD16bFcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3Low affinity Fc receptor
CD18Integrin β2, ITGB2, MFI7Adhesion, cell signaling
CD19B4, Leu-12Regulates B-cell development, activation and differentiation. Signal transduction
CD20B1, Bp35, MS4A1B-cell activation and proliferation
CD21C3DR, CR2, EBV-RSignal transduction. Regulator of complement activation
CD22 antigensBL-CAM, Siglec-2, Leu-14B-cell adhesion and signal transduction
CD23FcεRII, BLAST-2, FCER2, CLEC4JLow affinity receptor for IgE, ligand for CD19, CD21 and CD81. Key molecule for B-cell activation and growth
CD24BA-1, NectadrinRegulation of B-cell proliferation and differentiation
CD25Tac, p55, IL2RAReceptor for IL2
CD26DPP IV, DPP4, ADABP, ADCP2Exoprotease. HIV pathogenesis
CD27T14, TNFRSF 7, CD27L receptorCostimulation of B- and T-cell activation
CD28TP44, T44T-cell proliferation, survival, IL-2 production, and Th2 cell development
CD29Integrin β1, ITGB1, FNRBLymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration.
CD39Integrin β1, ITGB1, FNRBLymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration
CD30Ki-1, TNFRSF8Regulates lymphocyte proliferation and cell death. Activation of NF-κB
CD31PECAM-1Cell adhesion. Plays a key role in leukocyte trafficking across endothelium
CD32FCG2, FCGR2A1, FCGR2Regulation of B-cell function. Induces phagocytosis and mediator release.
CD32aFcγRII, FCGR2A,Fc gamma RIIAInnate and adaptive immune responses
CD32bFcγRII, FCGR2B,Fc gamma RIIBPhagocytosis of immune complexes and regulation of antibody production
CD33p67, Siglec-3Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis
CD34 Cell adhesion
CD35CR1, C3b/C4b receptorReceptor for complement components C3b and C4b. Mediates adhesion and phagocytosis
CD36GPIV, GP3B, GP4, SCARB3Cell adhesion, cholesterol transport, scavenger receptor
CD37TSPAN26,GP52-40Signal transduction. Regulates T-cell proliferation
CD38T10, ADPRC1, ADP ribosyl cyclase 1Cell adhesion and signal transduction
CD39NTPDase 1, ENTPD1B-cell adhesion. Protects activated cells from lysis
CD40TNFRSF5Cell adhesion, cell proliferation, and signal transduction
CD41ITGA2BPlatelet activation and aggregation.
CD42bGP1BA, BSS, GP1B, VWDP, BDPLT3Cell adhesion, cell activation
CD42cGPIbb,GPIBBPlatelet adhesion and aggregation
CD43Leukosialin, sialophorin, SPNCell adhesion and T cell activation
CD44H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-IIICell adhesion and migration
CD45LCA, T200, B220, PTPRCCritical for B- and T-cell receptor mediated activation. Regullar of cell growth and differentiation
CD46MCP, TLXInhibitory complement activation
CD47IAP, MER6Cell adhesion and signal transduction
CD48Blast-1, BCM1Cell adhesion and T-cell costimulation
CD49bVLA-2, ITGA2Adhesion and platelet aggregation.
CD49cVLA-3, ITGA3Adhesion and signal transduction
CD49eVLA-5, ITGA5Adhesion, regulation of cell survival and apoptosis
CD49fVLA-6, ITGA6Embryogenesis, adhesion and cell migration
CD50ICAM-3Adhesion and costimulation
CD51Vitronectin receptor, ITGAV, MSK8Adhesion and signal transduction
CD52CAMPATH-1, HE5, CDW52Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity
CD53Tetraspanin-25, MOX44Signal transduction. Cell adhesion, activation, and migration
CD54ICAM-1Cell adhesion, lymphocyte activation, and migration
CD55DAFRegulates complement activation. Signal transduction
CD56NCAM1Homophilic and heterophilic adhesion
CD57B3GAT1, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1Adhesion molecule.
CD58LFA-3APC-T-cell adhesion. Killer target cell interaction.
CD59Protectin, MAC- inhibitorPrevents complement polymerization. Protects cells from complement mediated lysis
CD59a  
CD61GPIIIa, ITGB3, GP3ACell adhesion
CD62EE-selectin, ELAM-1, SELETumor cell adhesion and angiogenesis
CD62LL-selectin, LECAM-1, SELLLeukocyte rolling and homing on activated endothelium
CD62PP-selectin, PADGEM, SELP, LECAM3Cell adhesion
CD63LIMP, LAMP-3, MLA1Cell growth and motility regulation; complexes with integrins
CD64FcγRI, FCGR1, FCGR1AInnate and adaptive immune responses
CD66aBGP-1, NCA-160, CEACAM1Neutrophil activation, homophilic and heterophilic adhesion
CD66bCD67, CGM6, CEACAM8Cell adhesion and neutrophil activation
CD66cNCA, CEACAM6Cell adhesion and neutrophil activation
CD66dCGM1, CEACAM3Cell adhesion and neutrophil activation
CD66eCEA, CEACAM5Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD66fPSG1, Sp-1, PSBG1Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways
CD68Macrosialin, gp110, KP1Macrophage homing
CD69AIM, CLEC2C, EA1Signal transmission in NK cells and platelets
CD70Ki-24, CD27L, TNFSF7Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation.
CD71T9, TFRCControls iron uptake during cell proliferation
CD72Lyb-2, Ly-19, Ly-32B-cell activation and proliferation
CD735'-nucleotidase, NT5ENucleotidase
CD74LN2, Ii, DHLAGMHC class II antigen processing
CD75ST6GAL1, Sialyltransferase 1Functional maturation of B lymphocytes
CD77Gb3, Pk blood group, BLA, A4GALTInduces apoptosis
CD79aMB1, IGA, Ig-alphaSubunit of B-cell antigen receptor.Signal transduction
CD79bB29, IGB, Ig-betaSubunit of B-cell antigen receptor.Signal transduction
CD80B7, B7-1, BB1Costimulation of T-cell activation and proliferation.
CD81TAPA-1, Tetraspanin-28Signal transduction and Cell adhesion
CD82R2, KAI1, Tetraspanin-27Signal transduction
CD83HB15Antigen presentation and immune stimulation
CD84SLAM5Homophilic adhesion molecule. Enhances T-cell activation and cytokine production
CD85aLILRB3, ILT5, LIR3Immune regulation
CD85cLILRB5, LIR8Immune regulation
CD85dLILRB2, ILT4, LIR2, MIR10Down regulates the immune response and involved in the development of tolerance
CD85eLILRA3, ILT6, LIR4May be involved in triggering innate immune responses
CD85fLILRA5, ILT11, LIR9May be involved in triggering innate immune responses
CD85iLILRA1, LIR6May be involved in triggering innate immune responses
CD85jLILRB1, ILT2, LIR1Inhibits cytotoxicity in NK and T cells upon ligand binding
CD86B70, B7-2, CD28LG2Costimulation of T-cell activation and proliferation
CD87UPA-R, PLAUR, MO3Cell chemotaxis and adhesion
CD88C5A, C5AR, C5R1, C5AR1Cell activation
CD89FcαR, FCARIgA Fc receptor
CD90Thy-1Costimulation of lymphocytes and cell adhesion
CD91LRP1,A2MR,APOEREndocytic receptor involved in intracellular signaling, lipid homeostasis, and phagocytosis of apoptotic cells
CD93C1qR, C1QR1, MXRA4Cell adhesion and clearance of apoptotic cells
CD94KLRD1Inhibits NK function
CD95Apo-1, FASLG, APTL, TNFRSF6Induces apoptosis
CD96TACTILEInvolved in adhesive interactions of activated T cells and NK cells
CD97ADGRE5Neutrophil migration, cell adhesion and signaling
CD984F2hc, SLC3A2, MDU1Cell activation and cell aggregation
CD99MIC2, E2Leukocyte migration, T-cell activation and cell adhesion
CD100Semaphorin 4D, SEMA4DEnhancement of B-cell and dendritic cell responses
CD102ICAM-2Adhesion, costimulation and lymphocyte recirculation
CD103HUMINAE, ITGA1Lymphocyte retention. Receptor for E-cadherin.
CD104ITGB4, GP150Cell adhesion, and immune response
CD105Endoglin, ENG, ENDAngiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD106VCAM-1, L1CAMLeukocyte adhesion. Transmigration and costimulation of T-cells.
CD107aLAMP-1Cell adhesion
CD107bLAMP-2May be involved in leukocyte adhesion.Implicated in tumor cell metastasis
CD108Semaphorin 7A, SEMA7AMonocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development
CD111PVRL1, PRR1, Nectin-1, HVECEntry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms
CD112PVRL2, PRR2, Nectin-2, HVEBIntracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus
CD113PVRL3, Nectin-3Adhesion molecule that interacts with afadin
CD114GCSFR, CSF3RMyeloid cell proliferation and differentiation
CD115M-CSFR, c-fms, CSF1RMonocytic cell proliferation and differentiation
CD116GM-CSFRα, CSF2RA, GM-CSFRMyeloid cell hematopoiesis and differentiation
CD117c-kit, SCFR, KITCrucial for development of gonadal and pigment stem cells
CD118LIFR, gp190Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD119IFNγR, IFNGR1Receptor for interferon gamma, a multifunctional immunomodulator
CD120aTNFR-I, TNFRSF1A, TNFR1Receptor for TNF
CD120bTNFR-II, TNFRSF1B, TNFR2Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis
CD121aIL-1R type I, IL1R1, IL1R1, IL-1 RIReceptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD121bIL-1R, type II, IL1R2, IL-1R2Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD122IL-2Rβ, IL-2RBReceptor for IL2 and IL15
CD123IL-3R, IL3RAReceptor for IL3
CD124IL4RA, IL4RReceptor for IL4 and IL13
CD125IL5RA, IL5RReceptor for IL5
CD126IL-6R, IL6R, gp80Receptor for IL6
CD127IL-7R, IL7RReceptor for IL7
CD130IL-6Rβ, gp130, IL6STTransmits activities of IL6, IL11, LIF and CNF
CD131IL-3R common β, IL3RB, CSF2RB, IL5RBComponent of the high affinity IL3, GM-CSF and IL5 receptors
CD132IL2RG, Common γForms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15.
CD133PROM1, RP41, CORD12, PROML1, MSTP061CD133 has been proposed to act as an organizer of cell membrane topology.
CD134OX-40, TNFRSF4T-cell activation, proliferation and differentiation, apoptosis and cell adhesion
CD135Flt3, Flk2Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD136MSP-R, RON, PTK8, MST1RReceptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD137TNFRSF9, 4-1BB, CDw137, ILACostimulation of T-cell activation. Regulates T-cell-dependent immune responses.
CD137L4-1BB, TNFRSF9, ILACostimulation of T-cell activation
CD138Syndecan-1, SDCCell proliferation, cell migration, and cell-matrix interactions
CD140aPDGFRα, PDGFRACell proliferation, differentiation and survival
CD140bPDGFRβ, PDGFRBCell proliferation, differentiation and survival
CD141THBD, AHUS6, BDCA3, THPH12, THRM, TMActivation of protein C and initiation of protein C anti-coagulant pathway.
CD142Tissue Factor, F3Initiates blood clotting
CD143ACE1, DCP, DCP1, ICH, MVCD3Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin. Cell adhesion.
CD144VE-Cadherin, Cadherin-5Cell adhesion.
CD146MUC18, S-endo, MCAMCell adhesion. Involved in heterophilic cell to cell interactions
CD147Neurothelin, basoglin, Basigin, BSG,EMMPRINCell adhesion and T-cell activation
CD148HPTP-eta, DEP1, PTPRJTyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation
CD150SLAM, SLAMF1, IPO-3Costimulation of T-cells and B-cells
CD151PETA-3, GP27, SFA-1,Cell adhesion.
CD152CTLA-4T-cell inhibition
CD153CD30L, TNFSF8Binds to CD30 and induces proliferation of T-cells
CD154CD40L, CD40 Ligand, gp39, TRAPMediates B-cell proliferation, IgE production and is involved in immunoglobulin class switching
CD155PVR, NECL-5Mediates NK cell adhesion and triggers their effector functions.
CD156aADAM8Possible involvement in extravasation of leukocytes
CD156bADAM17, ADAM18, CSVP, NISBD, NISBD1, TACECleaves transmembrane form of TNF-α to generate the soluble active form.
CD156cADAM10Metalloprotease activity, cleaves many proteins including TNF-α and E-cadherin
CD157BST-1Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth
CD158ap58.1, KIR2DL1Inhibits the activity of NK cells
CD158b2NKAT-2, KIR2DL3Inhibits the activity of NK cells
CD158dKIR2DL4, KIR-103ASInhibits the activity of NK cells
CD158eKIR3DL1Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158zKIR3DL3Inhibits the activity of NK cells
CD159aNKG2A, KLRC1, NKG2Negative regulation of NK cell activation
CD160BY55, NK1Broad specificity receptor for MHC class I molecules
CD161NKR-P1A, KLRB1Inhibits NK cell mediated cytotoxicity. Induces immature thymocyte proliferation
CD162PSGL-1, SELPLGMediates rapid rolling of leukocytes over vascular surfaces during inflammation
CD163M130, MM130Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages.
CD164MGC-24, MUC-24Facilitates the adhesion of CD34+ cells to the stroma and negatively regulates their proliferation
CD166ALCAMMediates cell adhesion by binding to CD6 for intrathymic T-cell development
CD167aDDR1, MCK10Receptor tyrosine kinase involved in cell-cell interactions
CD167bDDR2Receptor tyrosine kinase involved in cell-cell interactions
CD170Siglec-5, CD33-like2, SIGLEC5, OB-BP2Adhesion molecule mediating sialic-acid dependent binding to cells
CD171NCAM-L1, L1CAMMultidomain cell adhesion molecule required for normal neurohistogenesis
CD172aSIRPα, SHPS-1, SIRPAImmunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172bSIRPβ, SIRB1Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172gSIRPγ, SIRPB2Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47
CD176Thomson Friedrenreich Ag, TRF1, TRFPotentially involved in cell adhesion
CD177NB1 glycoprotein, HNA-2aMajor immunogenic molecule of neutrophil membrane
CD178FasL, CD95L, FASLG, Fas LigandT-cell mediated cytotoxicity
CD179aVPREB1, IGI, IGVPB, VPREB 
CD179bIGLL1Early B-cell differentiation.
CD180RP-105Controls B-cell recognition and signaling of LPS. Leads to NFkB activation.
CD181CXCR1, C-C, CD128, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1CD181 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8).
CD182IL-8, GRO-α, β, γ, GCP-2, NAP-2, ENA-78CD182 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8)
CD183CXCR3T-cell chemotaxis, integrin activation, and adhesion
CD184CXCR4, FB22, HM89, LAP3, LCR1, NPYRCD184 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes.
CD185CXCR5, BLR1Homing and cell movement
CD186CXCR6, BONZO, STRL33, TYMSTRB-cell development
CD191CCR1, MIP-1αR, RANTES-RChemotaxis, adhesion
CD192CCR2, MCP-1-RLeukocyte chemotaxis and is an HIV co-receptor
CD193CCR3,CCL11, CCL7, CCL13, CCL5, HIV-1CD193 is a receptor for C-C type chemokines.CD193 is also known to be an entry co-receptor for HIV-1.
CD194CCR4, CKR4, K5-5, CMKBR4, ChemR13CD194 is a receptor for C-C type chemokines.
CD195CCR5, CKR5, CCCKR5, CMKBR5, IDDM22The CD195 belongs to the beta chemokine receptors family of integral membrane proteins.
CD196CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis.
CD197CCR7, BLR2, EBI1, CDw197, CMKBR7The protein encoded by this gene is a member of the G protein-coupled receptor family.
CD200OX-2, OX2Down-regulatory signal for myeloid cell function, costimulates T-cell proliferation
CD201EPC-R, PROCREnhances protein C activation
CD202bTie2, TekSignaling, migration and adhesion
CD204Macrophage scavenger-R, MSR1Endocytosis of macromolecules including low density lipoproteins, host defense
CD205DEC-205, LY75Phagocytosis, endocytosis
CD206MRC1, MMR, MRC1L1, CLEC13D, CLEC13DLCell adhesion, cell-cell signalling
CD207LangerinPathogen receptor and processing of antigen for presentation to T-cells
CD208DC-LAMP, LAMP3Dendritic cell maturation marker, involved in cell proliferation
CD209DC-SIGNMediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120
CD210IL10RA; IL10R; CD210a; HIL-10R; IL-10R1CD210 is tha receptor of IL-10.
CD212IL-12-R β1, IL12RB1Forms part of the receptor complexes for IL12 and IL23
CD213a1IL-13-R α1, IL13RA1Forms part of the receptor complexes for IL13 and IL4
CD213a2IL-13-R α2, IL13RA2Forms part of the receptor complex for IL13.
CD215IL15RAReceptor for IL15.
CD217IL-17R, IL17RAReceptor for IL17A and IL17F
CD218aIL-18Rα, IL-1Rrp, IL18R1Forms part of the receptor complex for IL18
CD218bIL-18Rβ, IL18RAPForms part of the receptor complex for IL18
CD220Insulin-R, Insulin Receptor, IINSRInsulin receptor
CD221IGF-1 R, IGF1RReceptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD223LAG-3Involved in lymphocyte activation, negative regulation of T-cell activation
CD224GGT1Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis.
CD225IFITM1, Leu-13, DSPA2aCell adhesion, cell growth and migration. Relays antiproliferative and homotypic adhesion signals
CD226DNAM-1, PTA-1, TLiSA1Intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells
CD227MUC1, EMA, PUM, Mucin 1Cell adhesion and signaling
CD228Melanotransferrin, MFI2Involved in cellular iron uptake
CD229Ly-9, LY9, SLAMF3Adhesion between T-cells and accessory cells
CD230Prion protein, PRNPOxidative stress homeostasis,cell survival, and signal transduction
CD231TALLA-1, A15, Tspan-7,Cell proliferation and motility
CD233Band 3, SLC4A1Anion exchanger across the cytoplasmic membrane, binding site for cytoskeletal proteins, enzymes and hemoglobin
CD235aGlycophorin A, GYPAMajor erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation, receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus
CD236Glycophorin C/D, GYPCGlycophorin-C regulates the stability of red cells
CD238Kell, KEL, Blood Group KellZinc endopeptidase cleaving endothelin 3. Contains the Kell blood group antigens
CD239B-CAM, BCAMLaminin alpha-5 receptor
CD242ICAM-4Ligand for the leukocyte adhesion protein LFA-1
CD2442B4, NAILNK cell activation, NK cell and T-cell interaction
CD247TCRz, CD3-ZEETACouples antigen recognition to several intracellular signaling pathways
CD249Aminopeptidase AM, EAP, ENPEPConverts angiotensin II to angiotensin III.
CD252OX40L, gp34Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
CD253TRAIL, Apo-2L, TL2, TNFSF10Induces cell death by apoptosis
CD254TNFSF11, RANKL, OPGL, ODFInvolved in dendritic cell maturation
CD256APRIL, TALL-2, TRDL-1, TNFSF13Important for B cell development
CD257BLyS, BAFF, TALL-1, TNFSF13BInvolved in the stimulation of B- and T-cell function and the regulation of humoral immunity
CD258LIGHT, HVEM-L, TNFRSF14Stimulates T-cell proliferation, receptor for Herpes simplex virus
CD261TRAIL-R1, DR4, TNFRSF10AInduces apoptosis, promotes activation of NFkB
CD262TRAIL-R2, DR5, TNFRSF10BActivated by TNFSF10 / TRAIL and transduces apoptosis signal
CD264DCR2, TRAIL-R4, TNFRSF10DReceptor for TRAIL, inhibits apoptosis
CD265RANK, TRANCE-R, ODFR, TNFRSF11AReceptor for TRANCE. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis
CD266TWEAK-R, FGF-inducible 14, TNFRSF12AReceptor for TWEAK. Promotes angiogenesis and the proliferation of endothelial cells.
CD267TACI, TNFR SF13B, TNFRSF13BReceptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB.
CD268BAFFR, TR13C,TNFRSF13CB-cell receptor for CD257. B-cell response
CD269BCMA, TNFRSF13B, TNFRSF17Receptor for CD256 and CD257, activates NFkB and JNK.
CD270HveA, TR2, TNFRSF14Receptor for CD258 and CD272.
CD271NGFR, p75 (NTR)Regulates neuronal growth, migration, differentiation and cell death during stem cells.
CD272BTLALymphocyte inhibitory receptor
CD273B7DC, PD-L2, PDCD1L2Stimulatory on dendritic cells, inhibits T-cell activation upon engaging the PD1 receptor.
CD274B7-H1, PD-L1Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition
CD275B7-H2, ICOSL, B7-RP1, GL50Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation
CD276B7-H3Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling
CD277BTN3A1, butyrophilin SF3 A1, BTF5T-cell activation
CD278ICOS, AILIMMediate cell-cell interactions, and effective help for antibody secretion by B-cells
CD279PD1, SLEB2Inhibitory cell surface receptor involved in T-cell tolerance
CD281TLR1Pathogen recognition and activation of innate immunity, regulates TLR2 function
CD282TLR2Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB
CD283TLR3Mediator of innate immunity against viral infection, activated by dsDNA
CD284TLR4Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons
CD286TLR6Receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins
CD292BMPR1A, ALK3, SKR5Receptor for BMP-2 and BMP-4
CD294PTGDR2, DP2, DL1R, CRTH2, GPR44Regulates immune and inflammatory response, induces Th2 cells, eosino and baso migration
CD295LeptinR, LEPR, OB-R, Leptin ReceptorReceptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis
CD296ART1, ARTC1Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins
CD297ART4, dombrock blood groupPlays a role in the metabolism of Dombrock blood group antigen
CD298ATP1B3, ATPB-3Component of Na+-K+ pump on neuronal membranes.
CD299DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M, DC-SIGNRPathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus
CD300aCMRF35H, IRC1, IRp60M, CLM-8NK cell function; also suppresses the effects of eotaxin, IL-5 and GM-CSF on neutrophils; and inhibits Ig-E dependent
CD300bCLM-7, IREM3, LMIR5, CMRF35-A2Activating immune receptor by interaction with TYROBP
CD300cCMRF35A, LIR, CLM-6Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells
CD300eCMRF35L, CLM-2, CMRF35-A5Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules
CD300fCLM-1, IREM-1, LMIR3Inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation
CD300gCLM-9, TREM4May mediate L-selectin-dependent lymphocyte rollings
CD301MGL, HML, CLEC10A, MGL1Cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding
CD302DCL1, BIMLECCell adhesion and migration
CD304BDCA4, neuropilin 1, CLEC4C, NRP1Angiogensis, axon guidance, cell survival, migration, and invasion
CD305LAIR1Negative regulator of NK, B, and T cells
CD306LAIR2Inhibits cellular activation and inflammation
CD307IRTA2, FCRL5May function in B-cells activation and differentiation
CD307aFCRL1May function in B-cells activation and differentiation.
CD307bFCRL2May function in B-cells activation and differentiation.
CD309VEGFR2, KDR, FLK-1Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD312ADGRE2, VBU, EMR2Involved in immune and inflammatory response
CD314NKG2D, KLRK1Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
CD315PTGFRN, CD9P-1, EWI-F, FPRP, SMAP-6Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor.
CD316EWI2, PGRL, CD81P3, KASP,IGSF8, EWI-2, KCT-4Negative regulator of cell motility.
CD317BST2, HM1.24IFN-induced antiviral host restriction factor
CD318CDCP1, SIMA135Cell differentiation, homing and dissemination. May also have a pro-survival role
CD319CRACC, SLAMF7Mediates NK cell activation and may play a role in lymphocyte adhesion
CD320FDC-SM-8D6, TCbIR, 8D6 antigenAugments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin
CD321JAM-A, JAM-1, PAM-1, F11RPlays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD322JAM-B, JAM-2, VE-JAMMay play a role in lymphocyte homing to secondary lymphoid organs
CD324E-Cadherin, Uvomorulin, CDH1, E-cadCalcium-dependent cell adhesion protein
CD325N-Cadherin, NCAD, CDH2In hippocampal cells, pancreatic cells and hepatocytes
CD326Ep-CAM, Ly74,, EGP314, TROP-1, TACSTD1A homotypic calcium-independent T-cell adhesion molecule
CD327SIGLEC6, OB-BP1Adhesion molecule that mediates sialic-acid dependent binding to cells
CD331FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAMReceptor for basic fibroblast growth factor.
CD332FGFR2, BEK, KGFRCell-surface receptor for fibroblast growth factors
CD333FGFR3, ACH, CEK2Cell-surface receptor for fibroblast growth factors
CD334FGFR4, JTK2, TKFCell-surface receptor for fibroblast growth factors
CD335NCR1, LY94, NKP46, NK-p46NK cell activation
CD336NKp44, Ly-95 homolog, NCR2Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis
CD337NKp30, Ly117, NCR3Cytotoxicity-activating receptor that contributes to the increased efficiency ofactivated NK cells to mediate tumor cell lysis
CD338ABCG2, BCRP, Bcrp1, MXRXenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain and cancer cells
CD339Jagged-1, JAG1, JAGL1, hJ1Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development
CD340ERBB2, MLN 19Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways
CD344Frizzled-4, Fz-4, FzD4Receptor for Wnt proteins
CD350Frizzled-10, Fz-10, FZD10Receptor for Wnt proteins
CD351FCAMR, Fcα/μRFc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity
CD352NTB-A, SLAMF6, LY108Triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors
CD353SLAMF8Regulates macrophage function; may play a role in B cell lineage commitment
CD354TREM-1Stimulates neutrophil and monocyte-mediated inflammatory responses.Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers
CD355CRTAMInteraction with CADM1 promotes NK cell cytotoxicity and IFN-gamma secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo
CD357TNFRSF18, GITRReceptor for TNFSF18
CD358TNFRSF21May activate NFkB and promote apoptosis. May activate JNK and be lymphocytes. involved in T-cell differentiation. Required for both normal cell body death and axonal pruning
CD360IL-21RReceptor for interleukin-21.
CD361EVI2, BEVDB, D17S376Cell adhesion, and immune response.
CD362Syndecan-2, HSPG, SDC2Cell surface proteoglycan that bears heparan sulfate
CD365HAVCR1, HAVCR, KIM-1, TIM, TIM-1, TIMD1as a stimulatory molecule for T-cell activation
CD366TIM-3, TIMD3T-cell exhaustion, immune checkpoint
CD367DCIR, DDB27, CLECSF6, CLEC4Acell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD368MCL, CLECSF8, CLEC-6, MPCL, CLEC4Dcell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD369DECTIN-1, CLECSF12, CLEC7Acell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD370HEEE9341, UNQ9341, DNGR1, CLEC9Acell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD371CLL-1, MICL, DCAL-2, CLEC12Acell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response

人类血细胞表面CD分子

细胞类型CD标记
干细胞CD34 +、CD31-CD117
所有白细胞CD45 +
粒细胞CD45+、CD11bCD15 +、CD24 +、CD114 +、CD182+
单核细胞CD4、CD45+、CD14 +、CD114 +、CD11a、CD11b、CD91+、 CD16 +
T淋巴细胞CD45+、CD3 +
辅助性T细胞CD45+、CD3+、CD4 +
T调节细胞CD4CD25FOXP3(一种转录因子)
细胞毒性T细胞CD45+、CD3+、CD8 +
B淋巴细胞CD45+、CD19 +、CD20 +、CD24 +、CD38CD22
血小板CD45+、CD61 +
自然杀伤细胞CD16 +、CD56 +、CD3-、CD31CD30、CD38

细胞因子及其受体

https://pmc.ncbi.nlm.nih.gov/articles/PMC2785020

部分重要的细胞因子

CytokinesPrincipal SourcePrimary Activity
GM-CSFTh cellsGrowth and differentiation of monocytes and dendritic cells
IL-1α
IL-β
Macrophages and other antigen
presenting cells (APCs)
Costimulation of APCs and T cells, inflammation and fever, acute phase response,
hematopoiesis
IL-2Activated Th1 cells, NK cellsProliferation of B cells and activated T cells, NK functions
IL-3Activated T cellsGrowth of hematopoietic progenitor cells
IL-4Activated T cellsB cell proliferation, eosinophil and mast cell growth and function, IgE and class II MHC
expression on B cells, inhibition of monokine production
IL-5Th2 and mast cellsEosinophil growth and function
IL-6Activated Th2 cells, APCs, other
somatic cells
Acute phase response, B cell proliferation, thrombopoiesis, synergistic with IL-1 and TNF on
T cells
IL-7Thymic and marrow stromal cellsT and B lymphopoiesis
IL-8macrophages, somatic cellsChemoattractant for neutrophils and T cells
IL-9T cellsHematopoietic and thymopoietic effects
IL-10Activated Th2 cells, CD8+ T and B
cells, macrophages
Inhibits cytokine production, promotes B cell proliferation and antibody production,
suppresses cellular immunity, mast cell growth
IL-11Atromal cellsSynergistic hematopoietic and thrombopoietic effects
IL-12B cells, macrophagesProliferation of NK cells, IFN production, promotes cell-mediated immune functions
IL-13Th2 cellsIL-4-like activities
IL-18Macrophagespotent inducer of interferon-+ by T cells and NK cells
IFN-α
IFN-β
Macrophages, neutrophils and
some somatic cells
Antiviral effects, induction of class I MHC on all somatic cells, activation of NK cells and
macrophages
IFN-γActivated Th1 and NK cellsInduces of class I MHC on all somatic cells, induces class II MHC on APCs and somatic
cells, activates macrophages, neutrophils, NK cells, promotes cell-mediated immunity,
antiviral effects
MIP-1αMacrophagesChemotaxis
MIP-1βLymphocytesChemotaxis
TGF-βT cells, monocytesChemotaxis, IL-1 synthesis, IgA synthesis, inhibit proliferation
TNF-αmacrophages, mast cells, NK
cells, sensory neurons
Cell death, inflammation, pain
TNF-βTh1 and Tc cellsphagocytosis, NO production, cell death

https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202004433

Table 1. Multiple cytokines related to different biological conditions

DiseasesRelate cytokinesReferences
Autoimmune diseasesIL-1, IL-2, IL-6, IL-12, IL-15, IL-16, IL-17, IL-18, IL-23,TNF-α, IFN-α, IFN-γ[62]
AllergyIL-1, IL-4, IL-5, IL-9, IL-10, IL-13[219]
Alzheimer's diseaseTNF-α, TGF-β, IL-1, IL-4, IL-6, IL-10[220]
AtherosclerosisTNF-α, IFN-γ, TGF-β, IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-20, IL-33, IL-37[221]
Cardiovascular disordersTNF-α, TGF-β, IL-1, IL-6, IL-10, IL-17, IL-18[51]
CancerTNF-α, TRAIL, IL-6, IL-10, IL-12, IL-17, IL-23[3]
DepressionTNF-α, IFN-γ, IL-1, IL-2, IL-6[222]
Gastrointestinal diseasesTNF-α, IFN-γ, TGF-β, IL-1, IL-4, IL-6, IL-8, IL-10[223]
SepsisTNF-α, IFN-γ, TGF-β, MIF, IL-1, IL-6, IL-4, IL-10, IL-12[224]
AgingIL-6, IL-8, IL-10, IL-13, TNF-α, IFN-γ[225]

Table 2 Common human cytokines and their receptors

NameSynonym(s)AminoChromosome AcidsMolecular Weight2Cytokine Receptor(s)(Da) and FormReceptor Location(s)
Interleukins      
IL-1-like      
IL-1αhematopoietin-12712q1430606CD121a, CDw121b2q12, 2q12-q22
IL-1βcatabolin2692q1420747CD121a, CDw121b2q12,2q12-q22
IL-1RAIL-1 receptor antagonist1772q14.220055CD121a2q12
IL-18interferon-γ inducing factor19311q22.2-q22.322326IL-18Rα, β2q12
Common g chain (CD132)      
IL-2T cell growth factor1534q26-q2717628CD25, 122,13210p15-p14, 22q13.1, Xq13.1
IL-4BSF-11535q31.117492CD124,213a13, 13216p11.2-12.1, X, Xq13.1
IL-7 1778q12-q1320186CD127, 1325p13, Xq13.1
IL-9T cell growth factor P401445q31.115909IL-9R, CD132Xq28 or Yq12, Xq13.1
IL-13P6001325q31.114319CD213a1, 213a2,X, Xq13.1-q28,
     CD1243, 13216p11.2-12.1, Xq13.1
IL-15 1624q3118086IL-15Ra, CD122, 13210p14-p14, 22q13.1, Xq13.1
Common b chain (CD131)      
IL-3multipotential CSF, MCGF1525q31.117233CD123, CDw131Xp22.3 or Yp11.3, 22q13.1
IL-5BCDF-11345q31.115238, homodimerCDw125, 1313p26-p24, 22q13.1
Also related      
GM-CSFCSF-21445q31.116295CD116, CDw131Xp22.32 or Yp11.2, 22q13.1
IL-6-like      
IL-6IFN-β2, BSF-22127p2123718CD126, 1301q21, 5q11
IL-11AGIF19919q13.3-13.421429IL-11Ra, CD1309p13, 5q11
Also related      
G-CSFCSF-320717q11.2-q1221781CD1141p35-p34.3
IL-12NK cell stimulatory factor219/3283p12-p13.2/24844/37169CD21219p13.1, 1p31.2
   5q31.1-q33.1heterodimer  
LIFleukemia inhibitory factor20222q12.1-q12.222008LIFR, CD1305p13-p12
OSMoncostatin M25222q12.1-q12.228484OSMR, CD1305p15.2-5p12
IL-10-like      
IL-10CSIF1781q31-q3220517, homodimerCDw21011q23
IL-20 1762q32.220437IL-20Rα, β?
Others      
IL-14HMW-BCGF498154759IL-14R?
IL-16LCF63115q2466694, homotetramerCD412pter-p12
IL-17CTLA-81552q3117504, homodimerCDw21722q11.1
Interferons      
IFN-α 1899p2221781CD11821q22.11
IFN-β 1879p2122294CD11821q22.11
IFN-γ 16612q1419348, homodimerCDw1196q23-q24
TNF      
CD154CD40L, TRAP261Xq2629273, homotrimerCD4020q12-q13.2
LT-β 2446p21.325390, heterotrimerLTβR12p13
TNF-αcachectin2336p21.325644, homotrimerCD120a, b12p13.2, 1p36.3-p36.2
TNF-βLT-α2056p21.322297, heterotrimerCD120a, b12p13.2, 1p36.3-p36.2
4-1BBL 25419p13.326624, trimer?CDw137 (4-1BB)1p36
APRILTALL-225017p13.127433, trimer?BCMA, TACI16p13.1, 17p11.2
CD70CD27L19319p1321146, trimer?CD2712p13
CD153CD30L2349q3326017, trimer?CD301p36
CD178FasL2811q2331485, trimer?CD95 (Fas)10q24.1
GITRL 1771q2320307, trimer?GITR1p36.3
LIGHT 24016p11.226351, trimer?LTbR, HVEM12p13, 1p36.3-p36.2
OX40L 1831q2521050, trimer?OX401p36
TALL-1 28513q32-q3431222, trimer?BCMA, TACI16p13.1, 17p11.2
TRAILApo2L2813q2632509, trimer?TRAILR1-48p21
TWEAKApo3L24917p13.327216, trimer?Apo31p36.2
TRANCEOPGL31713q1435478, trimer?RANK, OPG18q22.1, 8q24
TGF-β      
TGF-β1TGF-β39019q13.144341, homodimerTGF-βR19q22
TGF-β2 4141q4147747, homodimerTGF-βR23p22
TGF-β3 41214q2447328, homodimerTGF-βR31p33-p32
Miscellaneous hematopoietins      
Epoerythropoietin1937q2121306EpoR19p13.3-p13.2
TpoMGDF3533q26.3-q2737822TpoR1p34
Flt-3L 23519q13.126416Flt-313q12
SCFstem cell factor, c-kit ligand27312q2230898, homodimerCD1174q11-q12
M-CSFCSF-15541p21-p1360119, homodimerCD1155q33-q35
MSPMacrophage stimulating factor, MST-17113p2180379CDw1363p21.3

Table 3 Human chemokine and chemokine receptors

NameSynonym(s)Amino Acids2Ligand LocationMolecular Weight (Da)2Chemokine Receptor(s)Receptor Location
C Chemokines      
XCL1lymphoactin a, SCM-1a, ATAC1141q21-q2512517XCR13p21
XCL2lymphoactin b, SCM-1b, ATAC1141q2312567XCR13p21
CC Chemokines      
CCL1I-309961710992CCR83p22
CCL2MCP-1, MCAF9917q11.2-q1211025CCR23p21
CCL3MIP-1α, LD78α9217q11-q2110085CCR1, CCR53p21
CCL4MIP-1β, LAG-1, ACT-29217q11-q2310212CCR53p21
CCL5RANTES9117q11.2-q129990CCR1, CCR3, CCR53p21
CCL7MCP-39917q11.2-q1211200CCR1, CCR2, CCR33p21
CCL8MCP-29917q11.211246CCR33p21
CCL11eotaxin9717q21.1-q21.210732CCR33p21
CCL13MCP-49817q11.210986CCR2, CCR33p21
CCL14HCC-19317q11.210678CCR13p21
CCL15HCC-2, Lkn-1, MIP-1d, MIP-511317q11.212248CCR1, CCR33p21
CCL16HCC-4, LEC, LMC, LCC-112017q11.213600CCR13p21
CCL17TARC9416q1310507CCR43p24
CCL18DC-CK1, PARC, AMAC-a, MIP-48917q11.29849? 
CCL19MIP-3β, ELC, exodus-3989p1310993CCR717q12-q21.1
CCL20MIP-3α, LARC, exodus-1962q33-q3710762CCR66q27
CCL216Ckine, SLC, exodus-21349p1314646CCR717q12-q21.2
CCL22MDC, STCP-19316q1310580CCR43p22
CCL23MPIF-1, MIP-3, CKb-812017q11.213443CCR13p21
CCL24MPIF-2, eotaxin-2, CKb-61197q11.2313133CCR33p21
CCL25TECK, MIP-4a15019p13.216639CCR93p21
CCL26eotaxin-3947q11.210648CCR33p21
CCL27Eskine, CTACK, ILC1129p1312618CCR103p21
CXC ChemokinesELR?     
CXCL1GROa, MGSA-a +1074q2111301CXCR1, CXCR22q35
CXCL2GROb, MGSA-b, MIP-2a +1074q2111389CXCR22q35
CXCL3GROg, MGSA-g, MIP-2b +1074q2111342CXCR22q35
CXCL4PF4, oncostatin A -1014q12-q1310845? 
CXCL5ENA-78 +1144q13-q2111972CXCR22q35
CXCL6GCP-2 +1144q2111897CXCR1, CXCR22q35
CXCL7NAP-2, PPBP +3754q12-1342823CXCR22q35
CXCL8IL-8, NAP-1, NAF, MDNCF +994q12-1311098CXCR1, CXCR22q35
CXCL9Mig -1254q2114019CXCR3Xq13
CXCL10IP-10 -984q2110856CXCR3Xq13
CXCL11I-TAC -944q21.210365CXCR3Xq13
CXCL12SDF-1α/β -9310q11.110666CXCR42q21
CXCL13BLC, BCA-1 -1094q2112664CXCR511
CXCL14BRAK -995q3111722? 
CX3C Chemokines      
CX3CL1fractalkine39716q1342202CX3CR13p21

表格来源:https://www.ncbi.nlm.nih.gov/books/NBK6294/?log$=activity

人趋化因子、受体及效应

类别趋化因子来源受体募集的细胞主要效应
CXCCXCL8
(IL- 8)
单核细胞
巨噬细胞
成纤维细胞、上皮细胞
内皮细胞
CXCR1
CXCR2
中性粒细胞
初始T细胞
中性粒细胞的动员,
  激活和脱颗粒化
     血管生成
CXCL7
(PBP,β-TG,
NAP-2)
血小板CXCR2中性粒细胞激活中性粒细胞
凝块吸收
血管生成
CXCL1( GROa)
CXCL2(GROβ)
CXCL3(GROγ)
单核细胞
成纤维细胞
内皮细胞
CXCR2中性粒细胞
未成熟T细胞
成纤维细胞
激活中性粒细胞
纤维增生
血管生成
CCCCL3
(MIP-1α)
单核细胞
T细胞
肥大细胞
成纤维细胞
CCR1
CCR3
CCR5
单核细胞
NK和T细胞
嗜碱性粒细胞
DC
与HIV-1竞争
抗病毒防御
促进Th1免疫
CCL4
(MIP-1β)
单核巨噬细胞
中性粒细胞
内皮细胞
CCR1
CCR3
CCR5
单核细胞
NK和T细胞
DC
与HIV-1竞争
CCL2
(MCP -1)
单核细胞
巨噬细胞
成纤维细胞
角质形成细胞
CCR2B单核细胞
NK和T细胞
嗜碱性粒细胞
DC
激活巨噬细胞
嗜碱性粒细胞释放
组胺
促进Th2免疫
CCL5
( RANTES)
T细胞
内皮细胞
血小板
CCR1
CCR3
CCR5
单核细胞
NK和T细胞
嗜碱性粒细胞
嗜酸性粒细胞
DC
嗜碱性粒细胞脱颗粒化
激活T细胞
慢性炎症
CXXXCCX3CL1
(曲动蛋白)
单核细胞
内皮细胞
小胶质细胞
CX₃   CR1单核细胞
T细胞
白细胞-内皮黏附
脑炎

黏附分子

名称组织分布配体
选择素P选择素
(PADGEM、CD62P)
活化的内皮细胞
  与血小板
PSGL-1、s-Le×
E选择素
(ELAM1、CD62E)
 活化的内皮细胞s-Le
整合素aLβ₂ ( LFA-1,
CD¹1a:CD18)
单核细胞,T细胞,
巨噬细胞,中性粒细
胞,DC,NK细胞
ICAM-1、ICAM-2
am:B₂ (CR3,Mac-1,
   CD11b:CD18)
中性粒细胞,单核
细胞,巨噬细胞,
NK细胞
ICAM-1、iC3b、
纤维蛋白原
ax:B₂ (CR4,
p150.95,
CD11c:CD18)
DC,巨噬细胞,
中性粒细胞,NK细胞
iC3b
a₅ ;β₁ (VLA-5,
   CD49d:CD29)
单核细胞,巨噬细胞纤连蛋白
免疫球蛋白超家族ICAM-1(CD54)活化的内皮细胞和
活化的白细胞
LFA-1、Mac1
ICAM-2(CD102)静息内皮细胞、DCLFA-1
VCAM-1(CD106)活化内皮细胞VLA-4
PECAM(CD3 1)活化的白细胞和内
皮层细胞间的连接处
CD31

中性粒游走出血管壁过程

免疫学总结

写的比我详细多了(︶.̮︶✽)

https://www.sciencedirect.com/science/chapter/monograph/pii/B9780124200302000184