CD(分化抗原簇)
CD类别、分布、所属家族以及作用
Human leukocyte differentiation antigens
| CD no. | Session | Main antigen expression | Family |
|---|---|---|---|
| CD1a | T | Cortical mature thymocytes, dendritic cell subset, Langerhans cells | IgSF |
| CD1b | T | Cortical mature thymocytes, dendritic cell subset, Langerhans cells | |
| CD1c | T | Cortical mature thymocytes, dendritic cell subset, Langerhans cells, B cell subset | |
| CD1d | T | Cortical thymocytes, dendritic cell subset, Langerhans cells, intestinal epithelium | |
| CD1e | T | Cortical thymocytes, dendritic cell subset | |
| CD2 | T | Thymocytes, T cells, most NK cells, B cells | IgSF |
| CD2R | T | Activated T cells, NK cells | |
| CD3d | T | T cells | T cell receptor complex |
| CD3e | T | T cells | |
| CD3g | T | T cells | |
| CD3z | N | T cells, NK cells, macrophages | ND |
| CD4 | T | Helper/inducer T cells, monocyte subset, thymocyte subset, macrophages | IgSF |
| CD5 | T | Mature T cells, thymocytes, B cell subset | SRCR |
| CD6 | T | Mature T cells, B cell subset, medullary thymocytes | SRCR |
| CD7 | T | Mature T cells, NK cells, immature myeloid cell subset | IgSF |
| CD8a | T | Cytotoxic/suppressor T cells, NK cell subset, thymocytes | T cell coreceptor |
| CD8b | T | Cytotoxic/suppressor T cells, NK cell subset, thymocytes | |
| CD9 | P | Platelets, activated T cells, eosinophils, basophils, endothelial cells, pre-B cells | TM4SF |
| CD10 | B | Pre-B cell subset, B cell subset, cortical thymocyte subset, granulocytes, monocyte subset | Zinc metalloprotease |
| CD11a | Ad | Most of lymphoid and myeloid cells | Integrin a chain |
| CD11b | Ad | Myeloid cells and NK cells | Integrin a chain |
| CD11c | Ad | Myeloid cells, NK cells macrophages, activated T cells | Integrin a chain |
| CD11d | Ad | Leucocytes | Integrin a chain |
| CDw12 | M | Monocytes, granulocytes, platelets, NK cells | — |
| CD13 | M | Monocytes, neutrophils | — |
| CD14 | M | Monocytes, macrophages, Langerhans cells | LRG |
| CD15 | Ad | Neutrophils, eosinophils, monocytes, Reed Sternberg cells | Carbohydrate 2 |
| CD15s | Ad | Neutrophils, basophils, monocytes | Sialylated carbohydrate 2 |
| CD15u | Ca | ||
| CD16a | N | NK cells, macrophages, mast cells, monocytes | IgSF |
| CD16b | N | Granulocytes neutrophil only | IgSF |
| CDw17 | M | Neutrophils, basophils, monocytes, platelets, B cell subset | LacCer |
| CD18 | Ad | Leucocytes | Integrin |
| CD19 | B | Precursor B cells and B cells, follicular dendritic cells | IgSF |
| CD20 | B | Precursor B cell subset, B cells | CD20 family |
| CD21 | B | Mature B cells, follicular dendritic cells, thymocyte subset | RCA |
| CD22 | B | Precursor and mature B cells | IgSF |
| CD23 | B | B cells, monocytes, follicular dendritic cells | C-type lectin |
| CD24 | B | B cells, granulocytes | CD52/CD24/HSA |
| CD25 | Ck | Activated T and B cells, stimulated monocytes/macrophages | — |
| CD26 | X | Mature thymocytes, activated T cells, B cells, macrophages, NK cells | Serine-type exopeptidase |
| CD27 | T | Mature T cells, B cell subset, NK cells | TNF receptor family |
| CD28 | T | Mature thymocytes subset, T cells, plasma cells | IgSF |
| CD29 | Ad | Broad | Integrin |
| CD30 | X | Activated T and B cells, activated NK cells, monocytes, Reed Sternberg cells | TNF receptor family |
| CD31 | Ad | Platelets, endothelial cells, monocytes, NK cells, neutrophils, T cell subset | IgSF |
| CD32 | M | Broad except NK cells | Fc receptor |
| CD33 | M | Pan myeloid, majority of monocytic cells | Sialoadhesin family,IgSF |
| CD34 | M | Hematopoietic precursor cells, endothelial cells | Sialomucin |
| CD35 | M | Neutrophils, eosinophils, monocytes, follicular dendritic cells, B cells, erythrocytes, T cell subset RCA | |
| CD36 | P | Platelets, monocytes, macrophages, early erythroid cells, endothelial cells | — |
| CD37 | B | B cells, weak on T cells, monocytes, granulocytes | Tetraspan |
| CD38 | B | Plasma cells, majority of hemopoietic cells | ADP-ribosyl cyclase |
| CD39 | B | Mantle zone B cells, activated T cells, NK cells, dendritic cells, Langerhans cells, monocytes | Ecto-apyrase |
| CD40 | B | B cells, macrophages, follicular dendritic cells, endothelial cells, platelets | TNF/NGF receptor |
| CD41 | P | Platelets and platelet precursors | Integrin |
| CD42a | P | Platelets, megakaryocytes | LGR |
| CD42b | P | Platelets, megakaryocytes | LGR |
| CD42c | P | Platelets, megakaryocytes | LGR |
| CD42d | P | Platelets, megakaryocytes | LGR |
| CD43 | X | Broad, except resting B cells | Sialomucin |
| CD44 and CD44S | Ad | Most cell types | Hyaladherin |
| CD44R | Ad | Epithelial cells, monocytic cells | — |
| CD45 | X | All hematopoietic cells | PTPase |
| CD45RA | X | Naive resting T cells, medullary thymocytes | |
| CD45RB | X | ||
| CD45RC | X | ||
| CD45RO | X | Memory-activated T cells, cortical thymocytes | |
| CD46 | X | Broad | RCA |
| CD47 | Ad | Broad | IgSF |
| CD47R | X | Broad | |
| CD48 | X | Pan leukocyte | IgSF |
| CD49a | Ad | Activated T cells, monocytes, NK cells, endothelial cells | Integrin |
| CD49b | Ad | Platelets, megakaryocytes, NK cells, endothelial cells | Integrin |
| CD49c | Ad | Non-hematopoietic cells | Integrin |
| CD49d | Ad | Broad | Integrin |
| CD49e | Ad | Broad | Integrin |
| CD49f | Ad | Broad (except erythrocytes) | Integrin |
| CD50 | Ad | Leukocytes, endothelial cells, epidermal Langerhans cells | IgSF |
| CD51 | P | Platelets, endothelial cells, activated T cells, B cell subset | Integrin |
| CD52 | X | Thymocytes, lymphocytes, monocytes, macrophages | CD52/CD24/HSA |
| CD53 | X | Pan leukocyte | TM4SF |
| CD54 | Ad | Activated endothelial cells, activated T and B cells, monocytes | IgSF |
| CD55 | X | Broad | RCA |
| CD56 | N | NK cells, T cell subset | IgSF |
| CD57 | N | NK cell subset, T cell subset | — |
| CD58 | Ad | Broad | IgSF |
| CD59 | X | Broad | Ly6 |
| CD60a | Ca | T cell subset, platelets | Glycolipid |
| CD60b | Ca | Glycolipid | |
| CD60c | Ca | Glycolipid | |
| CD61 | P | Platelets, megakaryocytes | Integrin |
| CD62E | Ad | Endothelial cells | Selectin |
| CD62L | Ad | T and B cells, monocytes, granulocytes, some NK cells | Selectin |
| CD62P | Ad | Platelets, megakaryocytes, activated endothelial cells | Selectin |
| CD63 | P | Activated platelets, monocytes, degranulated neutrophils, endothelium | Tetraspan, TM4SF |
| CD64 | M | Monocytes, macrophages, dendritic cell subset | IgSF |
| CD65 | M | Granulocytes (monocytes) | poly-N-acetyllactosamine |
| CD65s | M | Granulocytes, monocytes | poly-N-acetyllactosamine |
| CD66a | M | Granulocytes and epithelial cells | IgSF, CEA |
| CD66b | M | Granulocytes | IgSF, CEA |
| CD66c | M | Granulocytes and epithelial cells | IgSF, CEA |
| CD66d | M | Granulocytes | IgSF, CEA |
| CD66e | M | Epithelial cells | IgSF, CEA |
| CD66f | M | Myeloid cell lines, fetal liver, placental syncytiotrophoblasts | IgSF, CEA |
| CD67 | cancelled: now CD66b | ||
| CD68 | M | Monocytes, macrophages, dendritic cells, neutrophils, myeloid progenitor cells | Sialomucin |
| CD69 | N | Activated T and B cells, thymocytes, NK cells, neutrophils, eosinophils | C-type lectin |
| CD70 | X | Activated B and T cells | TNF |
| CD71 | X | Proliferating cells, reticulocytes, erythroid precursors | Transferrin receptor |
| CD72 | B | Pan B, including progenitors | C-type lectin |
| CD73 | B | B and T cell subsets, follicular dendritic cells, epithelial cells, endothelial cells | GPI-anchored |
| CD74 | B | B cells, activated T cells, macrophages, activated epithelial and endothelial cells | — |
| CD75 | Ca | Mature B cells, T cell subset | Lactosamine |
| CD75s | Ca | Mature B cells, T cell subset | Sialylated lactosamine |
| CDw76 | cancelled: now CD75s | ||
| CD77 | B | Burkitt's lymphoma cells, germinal center B lymphocytes | Carbohydrate |
| CDw78 | cancelled | ||
| CD79a | B | B cells | IgSF |
| CD79b | B | B cells | IgSF |
| CD80 | B | Activated B and T cells, macrophages | IgSF |
| CD81 | B | Broad hemopoietic, endothelial and epithelial cells | Tetraspan |
| CD82 | B | Broad | Tetraspan |
| CD83 | B | Circulating and interdigitating reticular dendritic cells, Langerhans cells | IgSF, Siglec |
| CD84 | B | Mature B cells, monocytes, macrophages, platelets, thymocytes and T cell subset | — |
| CD85a | D | Monocytes, macrophages, granulocytes, dendritic cells, T cell subset | IgSF |
| CD85b | D | Monocytes, macrophages, dendritic cells | IgSF |
| CD85c | D | IgSF | |
| CD85d | D | Monocytes, macrophages, dendritic cells | IgSF |
| CD85e | D | Monocytes | IgSF |
| CD85f | D | IgSF | |
| CD85g | D | Monocytes | IgSF |
| CD85h | D | Monocytes, dendritic cell subset, macrophages, granulocytes, NK subset | IgSF |
| CD85i | D | Monocytes | IgSF |
| CD85j | D | Monocytes, macrophages, dendritic cells, NK subset, T cell subset, B cells | IgSF |
| CD85k | D | Monocytes, macrophages, dendritic cells | IgSF |
| CD85l | D | IgSF | |
| CD85m | D | IgSF | |
| CD86 | B | Memory B cells, monocytes, dendritic cells, endothelial cells and activated T cells | IgSF |
| CD87 | M | T cells, NK cells, monocytes and neutrophils as well as non-hemopoietic cells | GPI-anchored |
| CD88 | M | Granulocytes, monocytes, dendritic cells | Rhodopsin |
| CD89 | M | Myeloid cells | IgSF, Fc receptor, MIRR |
| CD90 | En | Hemopoietic stem cells, neurons | IgSF, GPI linked |
| CD91 | M | Monocytes, macrophages, neurons, fibroblasts | LDL receptor |
| CD92 | M | Monocytes, granulocytes | — |
| CDw93 | M | Monocytes, granulocytes, endothelial cells | |
| CD94 | N | NK cells, g/d and a/b T cell subsets | C-type lectin |
| CD95 | Ck | Broad including activated T and B cells | TNF/NGF receptor |
| CD96 | N | Activated T and NK cells | IgSF |
| CD97 | X | Activated T and B cells, monocytes, granulocytes | EGF-TM7 |
| CD98 | X | Broad on activated cells | |
| CD99 | T | Broad, including lymphocytes | |
| CD99R | T | Restricted hematopoietic expression | |
| CD100 | X | Broad | Semaphorin |
| CD101 | M | Granulocytes, monocytes, dendritic cells, activated T cells | IgSF |
| CD102 | Ad | Resting lymphocytes, monocytes, platelets, vascular endothelial cells | IgSF |
| CD103 | Ad | Mucosa associated T lymphocytes | Integrin |
| CD104 | Ad | Epithelial cells, keratinocytes, Schwann cells, monocytes, endothelial cells | Integrin |
| CD105 | En | Activated monocytes, endothelial cells, stromal cells, pre-B cells | TGF receptor |
| CD106 | En | Follicular dendritic cells, activated endothelium | IgSF |
| CD107a | P | Degranulated platelets, activated neutrophils, activated T cells | |
| CD107b | P | Degranulated platelets, activated neutrophils | |
| CD108 | X | Erythrocytes, circulating lymphocytes | |
| CD109 | Ca | Activated T cells and platelets, endothelial cells | |
| CD110 | P | Hematopietic stem and progenitor cells, megakaryocytes, platelets | IgSF |
| CD111 | M | CD34+ hematopoietic progenitors, epithelial and neuronal cells | IgSF |
| CD112 | M | CD34+ hematopoietic progenitors, epithelial and endothelial cells | IgSF |
| CD113 | NA (reserved) | ||
| CD114 | M | Granulocytes, monocytes, mature platelets, endothelial cells | Class I CK-R |
| CD115 | M | Monocytes, macrophages and their precursors, placenta | IgSF, tyrosine kinase R |
| CD116 | Ck | Macrophages, neutriphils, eosinophils, dendritic cells and their precursors | IgSF, class I CK-R |
| CD117 | Ck | Hematopoietic progenitor cells, tissue mast cells | IgSF, tyrosine kinase R |
| CD118 | NA (reserved) | ||
| CDw119 | Ck | Broad | IgSF, class II CK-R |
| CD120a | Ck | Broad | TNF receptor |
| CD120b | Ck | Broad | TNF receptor |
| CD121a | Ck | Broad | IgSF |
| CDw121b | Ck | B cells, myeloid cells, some T cells | IgSF |
| CD122 | Ck | NK cells, T cells and B cells, monocytes/macrophages | IgSF, CK-R |
| CD123 | Ck | Myeloid cells including early progenitors endothelial cells | IgSF, class I CK-R |
| CD124 | Ck | Broad | IgSF, CK-R |
| CDw125 | Ck | Eosinophils, activated B cells, basophils | IgSF, CK-R |
| CD126 | Ck | T cells, monocytes, activated B cells | IgSF, class I CK-R |
| CD127 | Ck | T cells, B cell precursors | IgSF, CK-R |
| CDw128a | Ck | Neutrophils, T cell subset, monocytes, endothelial cells, fibroblasts, platelets | Chemokine receptor |
| CDw128b | Ck | Neutrophils, T cell subset, monocytes, melanocytes | Chemokine receptor |
| CD129 | NA (reserved IL-9R) | ||
| CD130 | Ck | Broad | Class I CK-R |
| CDw131 | Ck | Myeloid cells, early B cells | Class I CK-R |
| CD132 | Ck | T and B cells, NK cells, monocytes/macrophages, neutrophils | Class I CK-R |
| CD133 | S | CD34+ hematopoietic progenitors, neural and endothelial stem cells | 5-TM |
| CD134 | Ck | Activated T cells | TNF/NGF receptor |
| CD135 | Ck | Early and lymphoid committed progenitors | Tyrosine kinase receptor |
| CDw136 | Ck | Broad | Tyrosine kinase receptor |
| CDw137 | Ck | T cells | TNF receptor |
| CD138 | Ad | Pre-B cells, plasma cells | Syndecan |
| CD139 | B | B cells, monocytes, granulocytes, follicular dendritic cells | — |
| CD140a | En | Fibroblasts, smooth muscle cells, platelets | Split-tyrosine kinase |
| CD140b | En | Fibroblasts, smooth muscle cells, monocytes, neutrophils, endothelial cells | Split-tyrosine kinase |
| CD141 | En | Endothelial cells, monocytes, neutrophils, megakaryocytes, platelets | C-type lectin |
| CD142 | En | Epithelial cells, stromal cells, keratinocytes | Serine protease cofactor |
| CD143 | En | Endothelial and epithelial cells, activated macrophages | Peptidylpeptidase |
| CD144 | En | Endothelial cells | Cadherin |
| CDw145 | En | Endothelial cells, some stromal cells | |
| CD146 | En | Endothelial cells, smooth muscle cells, activated T cells, melanoma cells | IgSF |
| CD147 | En | Leukocytes, red blood cells, platelets and endothelial cells | IgSF |
| CD148 | X | Granulocytes, monocytes, resting T cells, dendritic cells, platelets, fibroblasts | RPTPase type III, phosphatase |
| CDw149 | cancelled: now CD47R | ||
| CD150 | X | Thymocytes, B cells, T cell subset, dendritic cells, endothelial cells | IgSF |
| CD151 | P | Platelets, megakaryocytes, endothelial and epithelial cells | Tetraspan |
| CD152 | T | Activated T and B cells | IgSF |
| CD153 | T | Activated T cells, activated macrophages, neutrophils, B cells | TNF |
| CD154 | T | Activated CD4+T cells | TNF |
| CD155 | M | Monocytes, broad tissue distribution | IgSF |
| CD156a | M | Monocytes, neutrophils | ADAM |
| CD156b | M | Broad | ADAM |
| CD157 | M | Granulocytes, monocytes, bone marrow stromal cells | ADP-ribosyl cyclase |
| CD158a | N | NK cell subset, minor subset of T cells | IgSF |
| CD158b1 | N | NK cell subset, minor subset of T cells | IgSF |
| CD158b2 | N | NK cell subset, minor subset of T cells | IgSF |
| CD158c | N | NK cell subset, minor subset of T cells | IgSF |
| CD158d | N | NK cell subset, minor subset of T cells | IgSF |
| CD158e1 | N | NK cell subset, minor subset of T cells | IgSF |
| CD158e2 | N | NK cell subset, minor subset of T cells | IgSF |
| CD158f | N | NK cell subset, minor subset of T cells | IgSF |
| CD158g | N | NK cell subset, minor subset of T cells | IgSF |
| CD158h | N | NK cell subset, minor subset of T cells | IgSF |
| CD158i | N | NK cell subset, minor subset of T cells | IgSF |
| CD158j | N | NK cell subset, minor subset of T cells | IgSF |
| CD158k | N | NK cell subset, minor subset of T cells | IgSF |
| CD158z | N | NK cell subset, minor subset of T cells | IgSF |
| CD159a | N | NK cell subset, T cells, thymocytes | C-type lectin |
| CD160 | N | NK cells, cytotoxic T cells | IgSF |
| CD161 | N | NK cells, T cells | C-type lectin |
| CD162 | Ad | Monocytes, granulocytes, T cells, some B cells | Sialomucin |
| CD162R | N | NK cell subset | |
| CD163 | M | Monocytes, macrophages | Scavenger receptor |
| CD164 | Ad | Monocytes, B cells (weak expression), CD34+ progenitor cells, bone marrow stromal cells, epithelial cells | Sialomucin |
| CD165 | Ad | Lymphocyte subset, monocytes, platelets, thymocytes | |
| CD166 | Ad | Activated T cells, activated monocytes, epithelium fibroblasts, neurons | IgSF |
| CD167a | Ad | Epithelial cells | Kinases |
| CD168 | Ad | Broad | |
| CD169 | Ad | Macrophages | IgSF |
| CD170 | Ad | Neutrophils, macrophages | |
| CD171 | Ad | Neurons, some epithelial cells and some lymphoid and myelomonocytic cells | IgSF |
| CD172a | Ad | Stem cells, monocytes, T cell subset | |
| CD173 | Ca | Red blood cells, platelets, CD34 stem cell subset | Blood group antigen |
| CD174 | Ca | Epithelial and endothelial cells, granulocytes, CD34 stem cell subset | Blood group antigen |
| CD175 | Ca | Stem cell subset | |
| CD175s | Ca | Erythroblasts | |
| CD176 | Ca | Stem cell subset | |
| CD177 | M | Neutrophil subset | |
| CD178 | Ck | Lymphoid cells | TNF |
| CD179a | B | Pro-B and early pre-B cells | IgSF |
| CD179b | B | Pro-B and early pre-B cells | IgSF |
| CD180 | B | Mantle and marginal zone B cells, monocytes, dendritic cells | Toll-like receptor family |
| CD181-CD182 | NA (reserved) | ||
| CD183 | Ck | T cells, plasmacytoid dendritic cells, subsets of NK and B-cells, eosinophils | Chemokine receptor |
| CD184 | Ck | Broad in blood and tissue cells, CD34 stem cell subset | Chemokine receptor |
| CD185-CD194 | NA (reserved) | ||
| CD195 | Ck | Monocytes, T cell subset | |
| CD196 | NA (reserved) | ||
| CDw197 | Ck | Peripheral T and B cells, bone marrow and cord blood CD34+ HPC, dendritic cells | Chemokine receptor |
| CD198-CD199 | NA (reserved) | ||
| CD200 | X | Thymocytes, B cells, activated T cells | |
| CD201 | En | Endothelial cell subset | CD1/MHC super family |
| CD202b | En | Endothelial cells, stem cells | Tyrosine kinase receptor |
| CD203c | M | Basophils, mast cells | Ectoenzyme |
| CD204 | M | Macrophages | |
| CD205 | D | Dendritic cells | C-type lectin |
| CD206 | D | Dendritic cells, macrophages | C-type lectin |
| CD207 | D | Langerhans cells | C-type lectin |
| CD208 | D | Interdigitating dendritic cells, mature dendritic cells | LAMP family |
| CD209 | D | Dendritic cell subsets | C-type lectin |
| CDw210 | Ck | T and B cells, NK cells, monocytes, macrophages | |
| CD211 | NA (reserved) | ||
| CD212 | Ck | Activated T cells, activated NK cells | |
| CD213a1 | Ck | Basophils, mastocytes | |
| CD213a2 | Ck | B cells, monocytes | |
| CD214-CD216 | NA (reserved) | ||
| CDw217 | Ck | Monocytes, erythroblasts | |
| CD218-CD219 | NA (reserved) | ||
| CD220 | X | Broad | |
| CD221 | X | Broad | |
| CD222 | X | Broad | Lectins |
| CD223 | X | Activated T cells, activated NK cells | |
| CD224 | X | Vascular endothelium, peripheral blood macrophages, activated T cells, CD45RO+ T cells, B cell subset | Membrane-bound ectoenzyme |
| CD225 | X | Broad | |
| CD226 | T | NK cells, platelets, monocytes, subset of T cells, thymocytes | IgSF |
| CD227 | X | Granular and ductal epithelial cells | Mucin |
| CD228 | X | Melanoma cells, progenitor cells | Transferrin family, GPI anchor |
| CD229 | X | T and B cells | |
| CD230 | X | Broad | |
| CD231 | X | T cell acute lymphoblastic leukemia, neuroblastoma cells | TM4SF |
| CD232 | X | Broad | |
| CD233 | Q | Erythrocyte plasma membrane | Bicarbonate transporter |
| CD234 | Q | Erythroid cells, endothelial cells, some epithelial cells | Chemokine receptor |
| CD235a | Q | Red blood cells, erythroid precursor cells | |
| CD235b | Q | Red blood cells, erythroid precursor cells | |
| CD235ab | Q | Red blood cells, erythroid precursor cells | |
| CD236 | Q | Red blood cells, stem cell subset | |
| CD236R | Q | Red blood cells, stem cell subset | |
| CD237 | NA (reserved) | ||
| CD238 | Q | Red blood cells, stem cell subset | Neutral endopeptidase |
| CD239 | Q | Red blood cells, stem cell subset | IgSF |
| CD240CE | Q | Red blood cells | |
| CD240D | Q | Red blood cells | |
| CD240DCE | Q | Red blood cells | |
| CD241 | Q | Red blood cells | |
| CD242 | Q | Erythrocytes, lymphocytes | IgSF |
| CD243 | S | Stem cells, NK cells, T cells, Tumor cells | ABC transporters |
| CD244 | N | NK cells, T cell subset, monocytes, basophils | IgSF |
| CD245 | T | T cell subset | |
| CD246 | T | Anaplastic T cell leukemia | |
| CD247 | T | T cells, NK cells | |
Session keys:Ad
AdhesionB
B cellsCa
Carbohydrates/lectinsCk
Cytokines/chemokinesD
Dendritic cellsEn
Endothelial cellsEr
Erythroid cellsM
Myeloid cellsN
NK cellsP
PlateletsS
Stem cellsT
T cellsX
Blind panel
当然这里也有简化版本的(simply simplified in text merely actually())
| Name | Alias | Function |
| CD1a | R4,T6 | Antigen presenting protein |
| CD1b | T6 | Antigen presenting protein |
| CD1c | R7, CD1, CD1A, BDCA1 | Non peptide antigen presentation to T-cell receptors on NKT cells. |
| CD1d | R3G1 | Antigen presenting protein |
| CD2 | T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R | Adhesion between T-cells and other cell types and T-cell activation. |
| CD3d | T3D, IMD19, CD3-DELTA | T-cell activation signaling and regulation of TCR expression |
| CD3e | T3E, TCRE, CD3 epsilon | T-cell activation signaling and regulation of TCR expression |
| CD3g | T3G, IMD17, CD3-GAMMA | T-cell activation signaling and regulation of TCR expression |
| CD4 | T4 | T-cell activation, thymic differentiation and receptor for HIV |
| CD5 | T1, Tp67, LEU1 | Regulates T-cell receptor signaling |
| CD6 | T12, OX52, TP120 | T-cell activation and cell adhesion |
| CD7 | LEU 9, GP40, TP41 | T-cell interactions |
| CD8a | T8, Leu-2, MAL, CD8 alpha | Co-receptor for MHC class 1 molecules |
| CD8b | CD8B1, P37 | Co-receptor for MHC class 1 molecules |
| CD9 | p24, MRP-1, 5H9 antigen, MIC3, TSPAN29, GIG2 | Platelet activation and aggregation, and cell adhesion and cell motility |
| CD10 | CALLA, NEP, gp100, Neprilysin, SFE, MME, EPN | Peptidase, regulates B-cell growth |
| CD11a | LFA-1, LFA1A, ITGAL | Intracellular adhesion and costimulation. |
| CD11b | ITGAM, CR3A, MO1A, MAC-1, MAC1A, SLEB6 | Cell adhesion, and immune response |
| CD11c | p150, 95, CR4, integrin αX, LFA-1A, ITGAX | Cell adhesion |
| CD13 | Aminopeptidase N, APN, ANPEP,PEPN | Aminopeptidase |
| CD14 | LPS-R | Receptor for complex of LPS and LBP |
| CD15 | LeX, FUT4, ELFT, FCT3A, FUTIV, SSEA-1, FUC-TIV | CD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias |
| CD16a | FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3 | Low affinity Fc receptor. Mediates phagocytosis and antibody-dependent T-cell-mediated cytotoxicity |
| CD16b | FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 | Low affinity Fc receptor |
| CD18 | Integrin β2, ITGB2, MFI7 | Adhesion, cell signaling |
| CD19 | B4, Leu-12 | Regulates B-cell development, activation and differentiation. Signal transduction |
| CD20 | B1, Bp35, MS4A1 | B-cell activation and proliferation |
| CD21 | C3DR, CR2, EBV-R | Signal transduction. Regulator of complement activation |
| CD22 antigens | BL-CAM, Siglec-2, Leu-14 | B-cell adhesion and signal transduction |
| CD23 | FcεRII, BLAST-2, FCER2, CLEC4J | Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. Key molecule for B-cell activation and growth |
| CD24 | BA-1, Nectadrin | Regulation of B-cell proliferation and differentiation |
| CD25 | Tac, p55, IL2RA | Receptor for IL2 |
| CD26 | DPP IV, DPP4, ADABP, ADCP2 | Exoprotease. HIV pathogenesis |
| CD27 | T14, TNFRSF 7, CD27L receptor | Costimulation of B- and T-cell activation |
| CD28 | TP44, T44 | T-cell proliferation, survival, IL-2 production, and Th2 cell development |
| CD29 | Integrin β1, ITGB1, FNRB | Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration. |
| CD39 | Integrin β1, ITGB1, FNRB | Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration |
| CD30 | Ki-1, TNFRSF8 | Regulates lymphocyte proliferation and cell death. Activation of NF-κB |
| CD31 | PECAM-1 | Cell adhesion. Plays a key role in leukocyte trafficking across endothelium |
| CD32 | FCG2, FCGR2A1, FCGR2 | Regulation of B-cell function. Induces phagocytosis and mediator release. |
| CD32a | FcγRII, FCGR2A,Fc gamma RIIA | Innate and adaptive immune responses |
| CD32b | FcγRII, FCGR2B,Fc gamma RIIB | Phagocytosis of immune complexes and regulation of antibody production |
| CD33 | p67, Siglec-3 | Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis |
| CD34 | Cell adhesion | |
| CD35 | CR1, C3b/C4b receptor | Receptor for complement components C3b and C4b. Mediates adhesion and phagocytosis |
| CD36 | GPIV, GP3B, GP4, SCARB3 | Cell adhesion, cholesterol transport, scavenger receptor |
| CD37 | TSPAN26,GP52-40 | Signal transduction. Regulates T-cell proliferation |
| CD38 | T10, ADPRC1, ADP ribosyl cyclase 1 | Cell adhesion and signal transduction |
| CD39 | NTPDase 1, ENTPD1 | B-cell adhesion. Protects activated cells from lysis |
| CD40 | TNFRSF5 | Cell adhesion, cell proliferation, and signal transduction |
| CD41 | ITGA2B | Platelet activation and aggregation. |
| CD42b | GP1BA, BSS, GP1B, VWDP, BDPLT3 | Cell adhesion, cell activation |
| CD42c | GPIbb,GPIBB | Platelet adhesion and aggregation |
| CD43 | Leukosialin, sialophorin, SPN | Cell adhesion and T cell activation |
| CD44 | H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III | Cell adhesion and migration |
| CD45 | LCA, T200, B220, PTPRC | Critical for B- and T-cell receptor mediated activation. Regullar of cell growth and differentiation |
| CD46 | MCP, TLX | Inhibitory complement activation |
| CD47 | IAP, MER6 | Cell adhesion and signal transduction |
| CD48 | Blast-1, BCM1 | Cell adhesion and T-cell costimulation |
| CD49b | VLA-2, ITGA2 | Adhesion and platelet aggregation. |
| CD49c | VLA-3, ITGA3 | Adhesion and signal transduction |
| CD49e | VLA-5, ITGA5 | Adhesion, regulation of cell survival and apoptosis |
| CD49f | VLA-6, ITGA6 | Embryogenesis, adhesion and cell migration |
| CD50 | ICAM-3 | Adhesion and costimulation |
| CD51 | Vitronectin receptor, ITGAV, MSK8 | Adhesion and signal transduction |
| CD52 | CAMPATH-1, HE5, CDW52 | Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity |
| CD53 | Tetraspanin-25, MOX44 | Signal transduction. Cell adhesion, activation, and migration |
| CD54 | ICAM-1 | Cell adhesion, lymphocyte activation, and migration |
| CD55 | DAF | Regulates complement activation. Signal transduction |
| CD56 | NCAM1 | Homophilic and heterophilic adhesion |
| CD57 | B3GAT1, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1 | Adhesion molecule. |
| CD58 | LFA-3 | APC-T-cell adhesion. Killer target cell interaction. |
| CD59 | Protectin, MAC- inhibitor | Prevents complement polymerization. Protects cells from complement mediated lysis |
| CD59a | ||
| CD61 | GPIIIa, ITGB3, GP3A | Cell adhesion |
| CD62E | E-selectin, ELAM-1, SELE | Tumor cell adhesion and angiogenesis |
| CD62L | L-selectin, LECAM-1, SELL | Leukocyte rolling and homing on activated endothelium |
| CD62P | P-selectin, PADGEM, SELP, LECAM3 | Cell adhesion |
| CD63 | LIMP, LAMP-3, MLA1 | Cell growth and motility regulation; complexes with integrins |
| CD64 | FcγRI, FCGR1, FCGR1A | Innate and adaptive immune responses |
| CD66a | BGP-1, NCA-160, CEACAM1 | Neutrophil activation, homophilic and heterophilic adhesion |
| CD66b | CD67, CGM6, CEACAM8 | Cell adhesion and neutrophil activation |
| CD66c | NCA, CEACAM6 | Cell adhesion and neutrophil activation |
| CD66d | CGM1, CEACAM3 | Cell adhesion and neutrophil activation |
| CD66e | CEA, CEACAM5 | Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells |
| CD66f | PSG1, Sp-1, PSBG1 | Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways |
| CD68 | Macrosialin, gp110, KP1 | Macrophage homing |
| CD69 | AIM, CLEC2C, EA1 | Signal transmission in NK cells and platelets |
| CD70 | Ki-24, CD27L, TNFSF7 | Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation. |
| CD71 | T9, TFRC | Controls iron uptake during cell proliferation |
| CD72 | Lyb-2, Ly-19, Ly-32 | B-cell activation and proliferation |
| CD73 | 5'-nucleotidase, NT5E | Nucleotidase |
| CD74 | LN2, Ii, DHLAG | MHC class II antigen processing |
| CD75 | ST6GAL1, Sialyltransferase 1 | Functional maturation of B lymphocytes |
| CD77 | Gb3, Pk blood group, BLA, A4GALT | Induces apoptosis |
| CD79a | MB1, IGA, Ig-alpha | Subunit of B-cell antigen receptor.Signal transduction |
| CD79b | B29, IGB, Ig-beta | Subunit of B-cell antigen receptor.Signal transduction |
| CD80 | B7, B7-1, BB1 | Costimulation of T-cell activation and proliferation. |
| CD81 | TAPA-1, Tetraspanin-28 | Signal transduction and Cell adhesion |
| CD82 | R2, KAI1, Tetraspanin-27 | Signal transduction |
| CD83 | HB15 | Antigen presentation and immune stimulation |
| CD84 | SLAM5 | Homophilic adhesion molecule. Enhances T-cell activation and cytokine production |
| CD85a | LILRB3, ILT5, LIR3 | Immune regulation |
| CD85c | LILRB5, LIR8 | Immune regulation |
| CD85d | LILRB2, ILT4, LIR2, MIR10 | Down regulates the immune response and involved in the development of tolerance |
| CD85e | LILRA3, ILT6, LIR4 | May be involved in triggering innate immune responses |
| CD85f | LILRA5, ILT11, LIR9 | May be involved in triggering innate immune responses |
| CD85i | LILRA1, LIR6 | May be involved in triggering innate immune responses |
| CD85j | LILRB1, ILT2, LIR1 | Inhibits cytotoxicity in NK and T cells upon ligand binding |
| CD86 | B70, B7-2, CD28LG2 | Costimulation of T-cell activation and proliferation |
| CD87 | UPA-R, PLAUR, MO3 | Cell chemotaxis and adhesion |
| CD88 | C5A, C5AR, C5R1, C5AR1 | Cell activation |
| CD89 | FcαR, FCAR | IgA Fc receptor |
| CD90 | Thy-1 | Costimulation of lymphocytes and cell adhesion |
| CD91 | LRP1,A2MR,APOER | Endocytic receptor involved in intracellular signaling, lipid homeostasis, and phagocytosis of apoptotic cells |
| CD93 | C1qR, C1QR1, MXRA4 | Cell adhesion and clearance of apoptotic cells |
| CD94 | KLRD1 | Inhibits NK function |
| CD95 | Apo-1, FASLG, APTL, TNFRSF6 | Induces apoptosis |
| CD96 | TACTILE | Involved in adhesive interactions of activated T cells and NK cells |
| CD97 | ADGRE5 | Neutrophil migration, cell adhesion and signaling |
| CD98 | 4F2hc, SLC3A2, MDU1 | Cell activation and cell aggregation |
| CD99 | MIC2, E2 | Leukocyte migration, T-cell activation and cell adhesion |
| CD100 | Semaphorin 4D, SEMA4D | Enhancement of B-cell and dendritic cell responses |
| CD102 | ICAM-2 | Adhesion, costimulation and lymphocyte recirculation |
| CD103 | HUMINAE, ITGA1 | Lymphocyte retention. Receptor for E-cadherin. |
| CD104 | ITGB4, GP150 | Cell adhesion, and immune response |
| CD105 | Endoglin, ENG, END | Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1 |
| CD106 | VCAM-1, L1CAM | Leukocyte adhesion. Transmigration and costimulation of T-cells. |
| CD107a | LAMP-1 | Cell adhesion |
| CD107b | LAMP-2 | May be involved in leukocyte adhesion.Implicated in tumor cell metastasis |
| CD108 | Semaphorin 7A, SEMA7A | Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development |
| CD111 | PVRL1, PRR1, Nectin-1, HVEC | Entry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms |
| CD112 | PVRL2, PRR2, Nectin-2, HVEB | Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus |
| CD113 | PVRL3, Nectin-3 | Adhesion molecule that interacts with afadin |
| CD114 | GCSFR, CSF3R | Myeloid cell proliferation and differentiation |
| CD115 | M-CSFR, c-fms, CSF1R | Monocytic cell proliferation and differentiation |
| CD116 | GM-CSFRα, CSF2RA, GM-CSFR | Myeloid cell hematopoiesis and differentiation |
| CD117 | c-kit, SCFR, KIT | Crucial for development of gonadal and pigment stem cells |
| CD118 | LIFR, gp190 | Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion |
| CD119 | IFNγR, IFNGR1 | Receptor for interferon gamma, a multifunctional immunomodulator |
| CD120a | TNFR-I, TNFRSF1A, TNFR1 | Receptor for TNF |
| CD120b | TNFR-II, TNFRSF1B, TNFR2 | Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis |
| CD121a | IL-1R type I, IL1R1, IL1R1, IL-1 RI | Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling |
| CD121b | IL-1R, type II, IL1R2, IL-1R2 | Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling |
| CD122 | IL-2Rβ, IL-2RB | Receptor for IL2 and IL15 |
| CD123 | IL-3R, IL3RA | Receptor for IL3 |
| CD124 | IL4RA, IL4R | Receptor for IL4 and IL13 |
| CD125 | IL5RA, IL5R | Receptor for IL5 |
| CD126 | IL-6R, IL6R, gp80 | Receptor for IL6 |
| CD127 | IL-7R, IL7R | Receptor for IL7 |
| CD130 | IL-6Rβ, gp130, IL6ST | Transmits activities of IL6, IL11, LIF and CNF |
| CD131 | IL-3R common β, IL3RB, CSF2RB, IL5RB | Component of the high affinity IL3, GM-CSF and IL5 receptors |
| CD132 | IL2RG, Common γ | Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. |
| CD133 | PROM1, RP41, CORD12, PROML1, MSTP061 | CD133 has been proposed to act as an organizer of cell membrane topology. |
| CD134 | OX-40, TNFRSF4 | T-cell activation, proliferation and differentiation, apoptosis and cell adhesion |
| CD135 | Flt3, Flk2 | Receptor for MSP which regulates cell adhesion, motility, growth, and survival. |
| CD136 | MSP-R, RON, PTK8, MST1R | Receptor for MSP which regulates cell adhesion, motility, growth, and survival. |
| CD137 | TNFRSF9, 4-1BB, CDw137, ILA | Costimulation of T-cell activation. Regulates T-cell-dependent immune responses. |
| CD137L | 4-1BB, TNFRSF9, ILA | Costimulation of T-cell activation |
| CD138 | Syndecan-1, SDC | Cell proliferation, cell migration, and cell-matrix interactions |
| CD140a | PDGFRα, PDGFRA | Cell proliferation, differentiation and survival |
| CD140b | PDGFRβ, PDGFRB | Cell proliferation, differentiation and survival |
| CD141 | THBD, AHUS6, BDCA3, THPH12, THRM, TM | Activation of protein C and initiation of protein C anti-coagulant pathway. |
| CD142 | Tissue Factor, F3 | Initiates blood clotting |
| CD143 | ACE1, DCP, DCP1, ICH, MVCD3 | Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin. Cell adhesion. |
| CD144 | VE-Cadherin, Cadherin-5 | Cell adhesion. |
| CD146 | MUC18, S-endo, MCAM | Cell adhesion. Involved in heterophilic cell to cell interactions |
| CD147 | Neurothelin, basoglin, Basigin, BSG,EMMPRIN | Cell adhesion and T-cell activation |
| CD148 | HPTP-eta, DEP1, PTPRJ | Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation |
| CD150 | SLAM, SLAMF1, IPO-3 | Costimulation of T-cells and B-cells |
| CD151 | PETA-3, GP27, SFA-1, | Cell adhesion. |
| CD152 | CTLA-4 | T-cell inhibition |
| CD153 | CD30L, TNFSF8 | Binds to CD30 and induces proliferation of T-cells |
| CD154 | CD40L, CD40 Ligand, gp39, TRAP | Mediates B-cell proliferation, IgE production and is involved in immunoglobulin class switching |
| CD155 | PVR, NECL-5 | Mediates NK cell adhesion and triggers their effector functions. |
| CD156a | ADAM8 | Possible involvement in extravasation of leukocytes |
| CD156b | ADAM17, ADAM18, CSVP, NISBD, NISBD1, TACE | Cleaves transmembrane form of TNF-α to generate the soluble active form. |
| CD156c | ADAM10 | Metalloprotease activity, cleaves many proteins including TNF-α and E-cadherin |
| CD157 | BST-1 | Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth |
| CD158a | p58.1, KIR2DL1 | Inhibits the activity of NK cells |
| CD158b2 | NKAT-2, KIR2DL3 | Inhibits the activity of NK cells |
| CD158d | KIR2DL4, KIR-103AS | Inhibits the activity of NK cells |
| CD158e | KIR3DL1 | Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis. |
| CD158z | KIR3DL3 | Inhibits the activity of NK cells |
| CD159a | NKG2A, KLRC1, NKG2 | Negative regulation of NK cell activation |
| CD160 | BY55, NK1 | Broad specificity receptor for MHC class I molecules |
| CD161 | NKR-P1A, KLRB1 | Inhibits NK cell mediated cytotoxicity. Induces immature thymocyte proliferation |
| CD162 | PSGL-1, SELPLG | Mediates rapid rolling of leukocytes over vascular surfaces during inflammation |
| CD163 | M130, MM130 | Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages. |
| CD164 | MGC-24, MUC-24 | Facilitates the adhesion of CD34+ cells to the stroma and negatively regulates their proliferation |
| CD166 | ALCAM | Mediates cell adhesion by binding to CD6 for intrathymic T-cell development |
| CD167a | DDR1, MCK10 | Receptor tyrosine kinase involved in cell-cell interactions |
| CD167b | DDR2 | Receptor tyrosine kinase involved in cell-cell interactions |
| CD170 | Siglec-5, CD33-like2, SIGLEC5, OB-BP2 | Adhesion molecule mediating sialic-acid dependent binding to cells |
| CD171 | NCAM-L1, L1CAM | Multidomain cell adhesion molecule required for normal neurohistogenesis |
| CD172a | SIRPα, SHPS-1, SIRPA | Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. |
| CD172b | SIRPβ, SIRB1 | Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. |
| CD172g | SIRPγ, SIRPB2 | Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47 |
| CD176 | Thomson Friedrenreich Ag, TRF1, TRF | Potentially involved in cell adhesion |
| CD177 | NB1 glycoprotein, HNA-2a | Major immunogenic molecule of neutrophil membrane |
| CD178 | FasL, CD95L, FASLG, Fas Ligand | T-cell mediated cytotoxicity |
| CD179a | VPREB1, IGI, IGVPB, VPREB | |
| CD179b | IGLL1 | Early B-cell differentiation. |
| CD180 | RP-105 | Controls B-cell recognition and signaling of LPS. Leads to NFkB activation. |
| CD181 | CXCR1, C-C, CD128, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1 | CD181 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8). |
| CD182 | IL-8, GRO-α, β, γ, GCP-2, NAP-2, ENA-78 | CD182 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8) |
| CD183 | CXCR3 | T-cell chemotaxis, integrin activation, and adhesion |
| CD184 | CXCR4, FB22, HM89, LAP3, LCR1, NPYR | CD184 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. |
| CD185 | CXCR5, BLR1 | Homing and cell movement |
| CD186 | CXCR6, BONZO, STRL33, TYMSTR | B-cell development |
| CD191 | CCR1, MIP-1αR, RANTES-R | Chemotaxis, adhesion |
| CD192 | CCR2, MCP-1-R | Leukocyte chemotaxis and is an HIV co-receptor |
| CD193 | CCR3,CCL11, CCL7, CCL13, CCL5, HIV-1 | CD193 is a receptor for C-C type chemokines.CD193 is also known to be an entry co-receptor for HIV-1. |
| CD194 | CCR4, CKR4, K5-5, CMKBR4, ChemR13 | CD194 is a receptor for C-C type chemokines. |
| CD195 | CCR5, CKR5, CCCKR5, CMKBR5, IDDM22 | The CD195 belongs to the beta chemokine receptors family of integral membrane proteins. |
| CD196 | CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 | Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis. |
| CD197 | CCR7, BLR2, EBI1, CDw197, CMKBR7 | The protein encoded by this gene is a member of the G protein-coupled receptor family. |
| CD200 | OX-2, OX2 | Down-regulatory signal for myeloid cell function, costimulates T-cell proliferation |
| CD201 | EPC-R, PROCR | Enhances protein C activation |
| CD202b | Tie2, Tek | Signaling, migration and adhesion |
| CD204 | Macrophage scavenger-R, MSR1 | Endocytosis of macromolecules including low density lipoproteins, host defense |
| CD205 | DEC-205, LY75 | Phagocytosis, endocytosis |
| CD206 | MRC1, MMR, MRC1L1, CLEC13D, CLEC13DL | Cell adhesion, cell-cell signalling |
| CD207 | Langerin | Pathogen receptor and processing of antigen for presentation to T-cells |
| CD208 | DC-LAMP, LAMP3 | Dendritic cell maturation marker, involved in cell proliferation |
| CD209 | DC-SIGN | Mediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120 |
| CD210 | IL10RA; IL10R; CD210a; HIL-10R; IL-10R1 | CD210 is tha receptor of IL-10. |
| CD212 | IL-12-R β1, IL12RB1 | Forms part of the receptor complexes for IL12 and IL23 |
| CD213a1 | IL-13-R α1, IL13RA1 | Forms part of the receptor complexes for IL13 and IL4 |
| CD213a2 | IL-13-R α2, IL13RA2 | Forms part of the receptor complex for IL13. |
| CD215 | IL15RA | Receptor for IL15. |
| CD217 | IL-17R, IL17RA | Receptor for IL17A and IL17F |
| CD218a | IL-18Rα, IL-1Rrp, IL18R1 | Forms part of the receptor complex for IL18 |
| CD218b | IL-18Rβ, IL18RAP | Forms part of the receptor complex for IL18 |
| CD220 | Insulin-R, Insulin Receptor, IINSR | Insulin receptor |
| CD221 | IGF-1 R, IGF1R | Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals |
| CD223 | LAG-3 | Involved in lymphocyte activation, negative regulation of T-cell activation |
| CD224 | GGT1 | Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis. |
| CD225 | IFITM1, Leu-13, DSPA2a | Cell adhesion, cell growth and migration. Relays antiproliferative and homotypic adhesion signals |
| CD226 | DNAM-1, PTA-1, TLiSA1 | Intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells |
| CD227 | MUC1, EMA, PUM, Mucin 1 | Cell adhesion and signaling |
| CD228 | Melanotransferrin, MFI2 | Involved in cellular iron uptake |
| CD229 | Ly-9, LY9, SLAMF3 | Adhesion between T-cells and accessory cells |
| CD230 | Prion protein, PRNP | Oxidative stress homeostasis,cell survival, and signal transduction |
| CD231 | TALLA-1, A15, Tspan-7, | Cell proliferation and motility |
| CD233 | Band 3, SLC4A1 | Anion exchanger across the cytoplasmic membrane, binding site for cytoskeletal proteins, enzymes and hemoglobin |
| CD235a | Glycophorin A, GYPA | Major erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation, receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus |
| CD236 | Glycophorin C/D, GYPC | Glycophorin-C regulates the stability of red cells |
| CD238 | Kell, KEL, Blood Group Kell | Zinc endopeptidase cleaving endothelin 3. Contains the Kell blood group antigens |
| CD239 | B-CAM, BCAM | Laminin alpha-5 receptor |
| CD242 | ICAM-4 | Ligand for the leukocyte adhesion protein LFA-1 |
| CD244 | 2B4, NAIL | NK cell activation, NK cell and T-cell interaction |
| CD247 | TCRz, CD3-ZEETA | Couples antigen recognition to several intracellular signaling pathways |
| CD249 | Aminopeptidase AM, EAP, ENPEP | Converts angiotensin II to angiotensin III. |
| CD252 | OX40L, gp34 | Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production |
| CD253 | TRAIL, Apo-2L, TL2, TNFSF10 | Induces cell death by apoptosis |
| CD254 | TNFSF11, RANKL, OPGL, ODF | Involved in dendritic cell maturation |
| CD256 | APRIL, TALL-2, TRDL-1, TNFSF13 | Important for B cell development |
| CD257 | BLyS, BAFF, TALL-1, TNFSF13B | Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity |
| CD258 | LIGHT, HVEM-L, TNFRSF14 | Stimulates T-cell proliferation, receptor for Herpes simplex virus |
| CD261 | TRAIL-R1, DR4, TNFRSF10A | Induces apoptosis, promotes activation of NFkB |
| CD262 | TRAIL-R2, DR5, TNFRSF10B | Activated by TNFSF10 / TRAIL and transduces apoptosis signal |
| CD264 | DCR2, TRAIL-R4, TNFRSF10D | Receptor for TRAIL, inhibits apoptosis |
| CD265 | RANK, TRANCE-R, ODFR, TNFRSF11A | Receptor for TRANCE. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis |
| CD266 | TWEAK-R, FGF-inducible 14, TNFRSF12A | Receptor for TWEAK. Promotes angiogenesis and the proliferation of endothelial cells. |
| CD267 | TACI, TNFR SF13B, TNFRSF13B | Receptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB. |
| CD268 | BAFFR, TR13C,TNFRSF13C | B-cell receptor for CD257. B-cell response |
| CD269 | BCMA, TNFRSF13B, TNFRSF17 | Receptor for CD256 and CD257, activates NFkB and JNK. |
| CD270 | HveA, TR2, TNFRSF14 | Receptor for CD258 and CD272. |
| CD271 | NGFR, p75 (NTR) | Regulates neuronal growth, migration, differentiation and cell death during stem cells. |
| CD272 | BTLA | Lymphocyte inhibitory receptor |
| CD273 | B7DC, PD-L2, PDCD1L2 | Stimulatory on dendritic cells, inhibits T-cell activation upon engaging the PD1 receptor. |
| CD274 | B7-H1, PD-L1 | Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition |
| CD275 | B7-H2, ICOSL, B7-RP1, GL50 | Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation |
| CD276 | B7-H3 | Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling |
| CD277 | BTN3A1, butyrophilin SF3 A1, BTF5 | T-cell activation |
| CD278 | ICOS, AILIM | Mediate cell-cell interactions, and effective help for antibody secretion by B-cells |
| CD279 | PD1, SLEB2 | Inhibitory cell surface receptor involved in T-cell tolerance |
| CD281 | TLR1 | Pathogen recognition and activation of innate immunity, regulates TLR2 function |
| CD282 | TLR2 | Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB |
| CD283 | TLR3 | Mediator of innate immunity against viral infection, activated by dsDNA |
| CD284 | TLR4 | Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons |
| CD286 | TLR6 | Receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins |
| CD292 | BMPR1A, ALK3, SKR5 | Receptor for BMP-2 and BMP-4 |
| CD294 | PTGDR2, DP2, DL1R, CRTH2, GPR44 | Regulates immune and inflammatory response, induces Th2 cells, eosino and baso migration |
| CD295 | LeptinR, LEPR, OB-R, Leptin Receptor | Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis |
| CD296 | ART1, ARTC1 | Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins |
| CD297 | ART4, dombrock blood group | Plays a role in the metabolism of Dombrock blood group antigen |
| CD298 | ATP1B3, ATPB-3 | Component of Na+-K+ pump on neuronal membranes. |
| CD299 | DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M, DC-SIGNR | Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus |
| CD300a | CMRF35H, IRC1, IRp60M, CLM-8 | NK cell function; also suppresses the effects of eotaxin, IL-5 and GM-CSF on neutrophils; and inhibits Ig-E dependent |
| CD300b | CLM-7, IREM3, LMIR5, CMRF35-A2 | Activating immune receptor by interaction with TYROBP |
| CD300c | CMRF35A, LIR, CLM-6 | Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells |
| CD300e | CMRF35L, CLM-2, CMRF35-A5 | Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules |
| CD300f | CLM-1, IREM-1, LMIR3 | Inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation |
| CD300g | CLM-9, TREM4 | May mediate L-selectin-dependent lymphocyte rollings |
| CD301 | MGL, HML, CLEC10A, MGL1 | Cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding |
| CD302 | DCL1, BIMLEC | Cell adhesion and migration |
| CD304 | BDCA4, neuropilin 1, CLEC4C, NRP1 | Angiogensis, axon guidance, cell survival, migration, and invasion |
| CD305 | LAIR1 | Negative regulator of NK, B, and T cells |
| CD306 | LAIR2 | Inhibits cellular activation and inflammation |
| CD307 | IRTA2, FCRL5 | May function in B-cells activation and differentiation |
| CD307a | FCRL1 | May function in B-cells activation and differentiation. |
| CD307b | FCRL2 | May function in B-cells activation and differentiation. |
| CD309 | VEGFR2, KDR, FLK-1 | Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation |
| CD312 | ADGRE2, VBU, EMR2 | Involved in immune and inflammatory response |
| CD314 | NKG2D, KLRK1 | Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells |
| CD315 | PTGFRN, CD9P-1, EWI-F, FPRP, SMAP-6 | Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor. |
| CD316 | EWI2, PGRL, CD81P3, KASP,IGSF8, EWI-2, KCT-4 | Negative regulator of cell motility. |
| CD317 | BST2, HM1.24 | IFN-induced antiviral host restriction factor |
| CD318 | CDCP1, SIMA135 | Cell differentiation, homing and dissemination. May also have a pro-survival role |
| CD319 | CRACC, SLAMF7 | Mediates NK cell activation and may play a role in lymphocyte adhesion |
| CD320 | FDC-SM-8D6, TCbIR, 8D6 antigen | Augments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin |
| CD321 | JAM-A, JAM-1, PAM-1, F11R | Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation |
| CD322 | JAM-B, JAM-2, VE-JAM | May play a role in lymphocyte homing to secondary lymphoid organs |
| CD324 | E-Cadherin, Uvomorulin, CDH1, E-cad | Calcium-dependent cell adhesion protein |
| CD325 | N-Cadherin, NCAD, CDH2 | In hippocampal cells, pancreatic cells and hepatocytes |
| CD326 | Ep-CAM, Ly74,, EGP314, TROP-1, TACSTD1 | A homotypic calcium-independent T-cell adhesion molecule |
| CD327 | SIGLEC6, OB-BP1 | Adhesion molecule that mediates sialic-acid dependent binding to cells |
| CD331 | FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM | Receptor for basic fibroblast growth factor. |
| CD332 | FGFR2, BEK, KGFR | Cell-surface receptor for fibroblast growth factors |
| CD333 | FGFR3, ACH, CEK2 | Cell-surface receptor for fibroblast growth factors |
| CD334 | FGFR4, JTK2, TKF | Cell-surface receptor for fibroblast growth factors |
| CD335 | NCR1, LY94, NKP46, NK-p46 | NK cell activation |
| CD336 | NKp44, Ly-95 homolog, NCR2 | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis |
| CD337 | NKp30, Ly117, NCR3 | Cytotoxicity-activating receptor that contributes to the increased efficiency ofactivated NK cells to mediate tumor cell lysis |
| CD338 | ABCG2, BCRP, Bcrp1, MXR | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain and cancer cells |
| CD339 | Jagged-1, JAG1, JAGL1, hJ1 | Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development |
| CD340 | ERBB2, MLN 19 | Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways |
| CD344 | Frizzled-4, Fz-4, FzD4 | Receptor for Wnt proteins |
| CD350 | Frizzled-10, Fz-10, FZD10 | Receptor for Wnt proteins |
| CD351 | FCAMR, Fcα/μR | Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity |
| CD352 | NTB-A, SLAMF6, LY108 | Triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors |
| CD353 | SLAMF8 | Regulates macrophage function; may play a role in B cell lineage commitment |
| CD354 | TREM-1 | Stimulates neutrophil and monocyte-mediated inflammatory responses.Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers |
| CD355 | CRTAM | Interaction with CADM1 promotes NK cell cytotoxicity and IFN-gamma secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo |
| CD357 | TNFRSF18, GITR | Receptor for TNFSF18 |
| CD358 | TNFRSF21 | May activate NFkB and promote apoptosis. May activate JNK and be lymphocytes. involved in T-cell differentiation. Required for both normal cell body death and axonal pruning |
| CD360 | IL-21R | Receptor for interleukin-21. |
| CD361 | EVI2, BEVDB, D17S376 | Cell adhesion, and immune response. |
| CD362 | Syndecan-2, HSPG, SDC2 | Cell surface proteoglycan that bears heparan sulfate |
| CD365 | HAVCR1, HAVCR, KIM-1, TIM, TIM-1, TIMD1 | as a stimulatory molecule for T-cell activation |
| CD366 | TIM-3, TIMD3 | T-cell exhaustion, immune checkpoint |
| CD367 | DCIR, DDB27, CLECSF6, CLEC4A | cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response |
| CD368 | MCL, CLECSF8, CLEC-6, MPCL, CLEC4D | cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response |
| CD369 | DECTIN-1, CLECSF12, CLEC7A | cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response |
| CD370 | HEEE9341, UNQ9341, DNGR1, CLEC9A | cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response |
| CD371 | CLL-1, MICL, DCAL-2, CLEC12A | cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response |
人类血细胞表面CD分子
| 细胞类型 | CD标记 |
|---|---|
| 干细胞 | CD34 +、CD31-、CD117 |
| 所有白细胞群 | CD45 + |
| 粒细胞 | CD45+、CD11b、CD15 +、CD24 +、CD114 +、CD182+ |
| 单核细胞 | CD4、CD45+、CD14 +、CD114 +、CD11a、CD11b、CD91+、 CD16 + |
| T淋巴细胞 | CD45+、CD3 + |
| 辅助性T细胞 | CD45+、CD3+、CD4 + |
| T调节细胞 | CD4、CD25、FOXP3(一种转录因子) |
| 细胞毒性T细胞 | CD45+、CD3+、CD8 + |
| B淋巴细胞 | CD45+、CD19 +、CD20 +、CD24 +、CD38、CD22 |
| 血小板 | CD45+、CD61 + |
| 自然杀伤细胞 | CD16 +、CD56 +、CD3-、CD31、CD30、CD38 |
细胞因子及其受体

https://pmc.ncbi.nlm.nih.gov/articles/PMC2785020
部分重要的细胞因子
| Cytokines | Principal Source | Primary Activity |
|---|---|---|
| GM-CSF | Th cells | Growth and differentiation of monocytes and dendritic cells |
| IL-1α IL-β | Macrophages and other antigen presenting cells (APCs) | Costimulation of APCs and T cells, inflammation and fever, acute phase response, hematopoiesis |
| IL-2 | Activated Th1 cells, NK cells | Proliferation of B cells and activated T cells, NK functions |
| IL-3 | Activated T cells | Growth of hematopoietic progenitor cells |
| IL-4 | Activated T cells | B cell proliferation, eosinophil and mast cell growth and function, IgE and class II MHC expression on B cells, inhibition of monokine production |
| IL-5 | Th2 and mast cells | Eosinophil growth and function |
| IL-6 | Activated Th2 cells, APCs, other somatic cells | Acute phase response, B cell proliferation, thrombopoiesis, synergistic with IL-1 and TNF on T cells |
| IL-7 | Thymic and marrow stromal cells | T and B lymphopoiesis |
| IL-8 | macrophages, somatic cells | Chemoattractant for neutrophils and T cells |
| IL-9 | T cells | Hematopoietic and thymopoietic effects |
| IL-10 | Activated Th2 cells, CD8+ T and B cells, macrophages | Inhibits cytokine production, promotes B cell proliferation and antibody production, suppresses cellular immunity, mast cell growth |
| IL-11 | Atromal cells | Synergistic hematopoietic and thrombopoietic effects |
| IL-12 | B cells, macrophages | Proliferation of NK cells, IFN production, promotes cell-mediated immune functions |
| IL-13 | Th2 cells | IL-4-like activities |
| IL-18 | Macrophages | potent inducer of interferon-+ by T cells and NK cells |
| IFN-α IFN-β | Macrophages, neutrophils and some somatic cells | Antiviral effects, induction of class I MHC on all somatic cells, activation of NK cells and macrophages |
| IFN-γ | Activated Th1 and NK cells | Induces of class I MHC on all somatic cells, induces class II MHC on APCs and somatic cells, activates macrophages, neutrophils, NK cells, promotes cell-mediated immunity, antiviral effects |
| MIP-1α | Macrophages | Chemotaxis |
| MIP-1β | Lymphocytes | Chemotaxis |
| TGF-β | T cells, monocytes | Chemotaxis, IL-1 synthesis, IgA synthesis, inhibit proliferation |
| TNF-α | macrophages, mast cells, NK cells, sensory neurons | Cell death, inflammation, pain |
| TNF-β | Th1 and Tc cells | phagocytosis, NO production, cell death |
https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202004433
Table 1. Multiple cytokines related to different biological conditions
| Diseases | Relate cytokines | References |
|---|---|---|
| Autoimmune diseases | IL-1, IL-2, IL-6, IL-12, IL-15, IL-16, IL-17, IL-18, IL-23,TNF-α, IFN-α, IFN-γ | [62] |
| Allergy | IL-1, IL-4, IL-5, IL-9, IL-10, IL-13 | [219] |
| Alzheimer's disease | TNF-α, TGF-β, IL-1, IL-4, IL-6, IL-10 | [220] |
| Atherosclerosis | TNF-α, IFN-γ, TGF-β, IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-20, IL-33, IL-37 | [221] |
| Cardiovascular disorders | TNF-α, TGF-β, IL-1, IL-6, IL-10, IL-17, IL-18 | [51] |
| Cancer | TNF-α, TRAIL, IL-6, IL-10, IL-12, IL-17, IL-23 | [3] |
| Depression | TNF-α, IFN-γ, IL-1, IL-2, IL-6 | [222] |
| Gastrointestinal diseases | TNF-α, IFN-γ, TGF-β, IL-1, IL-4, IL-6, IL-8, IL-10 | [223] |
| Sepsis | TNF-α, IFN-γ, TGF-β, MIF, IL-1, IL-6, IL-4, IL-10, IL-12 | [224] |
| Aging | IL-6, IL-8, IL-10, IL-13, TNF-α, IFN-γ | [225] |
Table 2 Common human cytokines and their receptors
| Name | Synonym(s) | Amino | Chromosome Acids | Molecular Weight2 | Cytokine Receptor(s)(Da) and Form | Receptor Location(s) |
|---|---|---|---|---|---|---|
| Interleukins | ||||||
| IL-1-like | ||||||
| IL-1α | hematopoietin-1 | 271 | 2q14 | 30606 | CD121a, CDw121b | 2q12, 2q12-q22 |
| IL-1β | catabolin | 269 | 2q14 | 20747 | CD121a, CDw121b | 2q12,2q12-q22 |
| IL-1RA | IL-1 receptor antagonist | 177 | 2q14.2 | 20055 | CD121a | 2q12 |
| IL-18 | interferon-γ inducing factor | 193 | 11q22.2-q22.3 | 22326 | IL-18Rα, β | 2q12 |
| Common g chain (CD132) | ||||||
| IL-2 | T cell growth factor | 153 | 4q26-q27 | 17628 | CD25, 122,132 | 10p15-p14, 22q13.1, Xq13.1 |
| IL-4 | BSF-1 | 153 | 5q31.1 | 17492 | CD124,213a13, 132 | 16p11.2-12.1, X, Xq13.1 |
| IL-7 | 177 | 8q12-q13 | 20186 | CD127, 132 | 5p13, Xq13.1 | |
| IL-9 | T cell growth factor P40 | 144 | 5q31.1 | 15909 | IL-9R, CD132 | Xq28 or Yq12, Xq13.1 |
| IL-13 | P600 | 132 | 5q31.1 | 14319 | CD213a1, 213a2, | X, Xq13.1-q28, |
| CD1243, 132 | 16p11.2-12.1, Xq13.1 | |||||
| IL-15 | 162 | 4q31 | 18086 | IL-15Ra, CD122, 132 | 10p14-p14, 22q13.1, Xq13.1 | |
| Common b chain (CD131) | ||||||
| IL-3 | multipotential CSF, MCGF | 152 | 5q31.1 | 17233 | CD123, CDw131 | Xp22.3 or Yp11.3, 22q13.1 |
| IL-5 | BCDF-1 | 134 | 5q31.1 | 15238, homodimer | CDw125, 131 | 3p26-p24, 22q13.1 |
| Also related | ||||||
| GM-CSF | CSF-2 | 144 | 5q31.1 | 16295 | CD116, CDw131 | Xp22.32 or Yp11.2, 22q13.1 |
| IL-6-like | ||||||
| IL-6 | IFN-β2, BSF-2 | 212 | 7p21 | 23718 | CD126, 130 | 1q21, 5q11 |
| IL-11 | AGIF | 199 | 19q13.3-13.4 | 21429 | IL-11Ra, CD130 | 9p13, 5q11 |
| Also related | ||||||
| G-CSF | CSF-3 | 207 | 17q11.2-q12 | 21781 | CD114 | 1p35-p34.3 |
| IL-12 | NK cell stimulatory factor | 219/328 | 3p12-p13.2/ | 24844/37169 | CD212 | 19p13.1, 1p31.2 |
| 5q31.1-q33.1 | heterodimer | |||||
| LIF | leukemia inhibitory factor | 202 | 22q12.1-q12.2 | 22008 | LIFR, CD130 | 5p13-p12 |
| OSM | oncostatin M | 252 | 22q12.1-q12.2 | 28484 | OSMR, CD130 | 5p15.2-5p12 |
| IL-10-like | ||||||
| IL-10 | CSIF | 178 | 1q31-q32 | 20517, homodimer | CDw210 | 11q23 |
| IL-20 | 176 | 2q32.2 | 20437 | IL-20Rα, β | ? | |
| Others | ||||||
| IL-14 | HMW-BCGF | 498 | 1 | 54759 | IL-14R | ? |
| IL-16 | LCF | 631 | 15q24 | 66694, homotetramer | CD4 | 12pter-p12 |
| IL-17 | CTLA-8 | 155 | 2q31 | 17504, homodimer | CDw217 | 22q11.1 |
| Interferons | ||||||
| IFN-α | 189 | 9p22 | 21781 | CD118 | 21q22.11 | |
| IFN-β | 187 | 9p21 | 22294 | CD118 | 21q22.11 | |
| IFN-γ | 166 | 12q14 | 19348, homodimer | CDw119 | 6q23-q24 | |
| TNF | ||||||
| CD154 | CD40L, TRAP | 261 | Xq26 | 29273, homotrimer | CD40 | 20q12-q13.2 |
| LT-β | 244 | 6p21.3 | 25390, heterotrimer | LTβR | 12p13 | |
| TNF-α | cachectin | 233 | 6p21.3 | 25644, homotrimer | CD120a, b | 12p13.2, 1p36.3-p36.2 |
| TNF-β | LT-α | 205 | 6p21.3 | 22297, heterotrimer | CD120a, b | 12p13.2, 1p36.3-p36.2 |
| 4-1BBL | 254 | 19p13.3 | 26624, trimer? | CDw137 (4-1BB) | 1p36 | |
| APRIL | TALL-2 | 250 | 17p13.1 | 27433, trimer? | BCMA, TACI | 16p13.1, 17p11.2 |
| CD70 | CD27L | 193 | 19p13 | 21146, trimer? | CD27 | 12p13 |
| CD153 | CD30L | 234 | 9q33 | 26017, trimer? | CD30 | 1p36 |
| CD178 | FasL | 281 | 1q23 | 31485, trimer? | CD95 (Fas) | 10q24.1 |
| GITRL | 177 | 1q23 | 20307, trimer? | GITR | 1p36.3 | |
| LIGHT | 240 | 16p11.2 | 26351, trimer? | LTbR, HVEM | 12p13, 1p36.3-p36.2 | |
| OX40L | 183 | 1q25 | 21050, trimer? | OX40 | 1p36 | |
| TALL-1 | 285 | 13q32-q34 | 31222, trimer? | BCMA, TACI | 16p13.1, 17p11.2 | |
| TRAIL | Apo2L | 281 | 3q26 | 32509, trimer? | TRAILR1-4 | 8p21 |
| TWEAK | Apo3L | 249 | 17p13.3 | 27216, trimer? | Apo3 | 1p36.2 |
| TRANCE | OPGL | 317 | 13q14 | 35478, trimer? | RANK, OPG | 18q22.1, 8q24 |
| TGF-β | ||||||
| TGF-β1 | TGF-β | 390 | 19q13.1 | 44341, homodimer | TGF-βR1 | 9q22 |
| TGF-β2 | 414 | 1q41 | 47747, homodimer | TGF-βR2 | 3p22 | |
| TGF-β3 | 412 | 14q24 | 47328, homodimer | TGF-βR3 | 1p33-p32 | |
| Miscellaneous hematopoietins | ||||||
| Epo | erythropoietin | 193 | 7q21 | 21306 | EpoR | 19p13.3-p13.2 |
| Tpo | MGDF | 353 | 3q26.3-q27 | 37822 | TpoR | 1p34 |
| Flt-3L | 235 | 19q13.1 | 26416 | Flt-3 | 13q12 | |
| SCF | stem cell factor, c-kit ligand | 273 | 12q22 | 30898, homodimer | CD117 | 4q11-q12 |
| M-CSF | CSF-1 | 554 | 1p21-p13 | 60119, homodimer | CD115 | 5q33-q35 |
| MSP | Macrophage stimulating factor, MST-1 | 711 | 3p21 | 80379 | CDw136 | 3p21.3 |
Table 3 Human chemokine and chemokine receptors
| Name | Synonym(s) | Amino Acids2 | Ligand Location | Molecular Weight (Da)2 | Chemokine Receptor(s) | Receptor Location |
|---|---|---|---|---|---|---|
| C Chemokines | ||||||
| XCL1 | lymphoactin a, SCM-1a, ATAC | 114 | 1q21-q25 | 12517 | XCR1 | 3p21 |
| XCL2 | lymphoactin b, SCM-1b, ATAC | 114 | 1q23 | 12567 | XCR1 | 3p21 |
| CC Chemokines | ||||||
| CCL1 | I-309 | 96 | 17 | 10992 | CCR8 | 3p22 |
| CCL2 | MCP-1, MCAF | 99 | 17q11.2-q12 | 11025 | CCR2 | 3p21 |
| CCL3 | MIP-1α, LD78α | 92 | 17q11-q21 | 10085 | CCR1, CCR5 | 3p21 |
| CCL4 | MIP-1β, LAG-1, ACT-2 | 92 | 17q11-q23 | 10212 | CCR5 | 3p21 |
| CCL5 | RANTES | 91 | 17q11.2-q12 | 9990 | CCR1, CCR3, CCR5 | 3p21 |
| CCL7 | MCP-3 | 99 | 17q11.2-q12 | 11200 | CCR1, CCR2, CCR3 | 3p21 |
| CCL8 | MCP-2 | 99 | 17q11.2 | 11246 | CCR3 | 3p21 |
| CCL11 | eotaxin | 97 | 17q21.1-q21.2 | 10732 | CCR3 | 3p21 |
| CCL13 | MCP-4 | 98 | 17q11.2 | 10986 | CCR2, CCR3 | 3p21 |
| CCL14 | HCC-1 | 93 | 17q11.2 | 10678 | CCR1 | 3p21 |
| CCL15 | HCC-2, Lkn-1, MIP-1d, MIP-5 | 113 | 17q11.2 | 12248 | CCR1, CCR3 | 3p21 |
| CCL16 | HCC-4, LEC, LMC, LCC-1 | 120 | 17q11.2 | 13600 | CCR1 | 3p21 |
| CCL17 | TARC | 94 | 16q13 | 10507 | CCR4 | 3p24 |
| CCL18 | DC-CK1, PARC, AMAC-a, MIP-4 | 89 | 17q11.2 | 9849 | ? | |
| CCL19 | MIP-3β, ELC, exodus-3 | 98 | 9p13 | 10993 | CCR7 | 17q12-q21.1 |
| CCL20 | MIP-3α, LARC, exodus-1 | 96 | 2q33-q37 | 10762 | CCR6 | 6q27 |
| CCL21 | 6Ckine, SLC, exodus-2 | 134 | 9p13 | 14646 | CCR7 | 17q12-q21.2 |
| CCL22 | MDC, STCP-1 | 93 | 16q13 | 10580 | CCR4 | 3p22 |
| CCL23 | MPIF-1, MIP-3, CKb-8 | 120 | 17q11.2 | 13443 | CCR1 | 3p21 |
| CCL24 | MPIF-2, eotaxin-2, CKb-6 | 119 | 7q11.23 | 13133 | CCR3 | 3p21 |
| CCL25 | TECK, MIP-4a | 150 | 19p13.2 | 16639 | CCR9 | 3p21 |
| CCL26 | eotaxin-3 | 94 | 7q11.2 | 10648 | CCR3 | 3p21 |
| CCL27 | Eskine, CTACK, ILC | 112 | 9p13 | 12618 | CCR10 | 3p21 |
| CXC Chemokines | ELR? | |||||
| CXCL1 | GROa, MGSA-a + | 107 | 4q21 | 11301 | CXCR1, CXCR2 | 2q35 |
| CXCL2 | GROb, MGSA-b, MIP-2a + | 107 | 4q21 | 11389 | CXCR2 | 2q35 |
| CXCL3 | GROg, MGSA-g, MIP-2b + | 107 | 4q21 | 11342 | CXCR2 | 2q35 |
| CXCL4 | PF4, oncostatin A - | 101 | 4q12-q13 | 10845 | ? | |
| CXCL5 | ENA-78 + | 114 | 4q13-q21 | 11972 | CXCR2 | 2q35 |
| CXCL6 | GCP-2 + | 114 | 4q21 | 11897 | CXCR1, CXCR2 | 2q35 |
| CXCL7 | NAP-2, PPBP + | 375 | 4q12-13 | 42823 | CXCR2 | 2q35 |
| CXCL8 | IL-8, NAP-1, NAF, MDNCF + | 99 | 4q12-13 | 11098 | CXCR1, CXCR2 | 2q35 |
| CXCL9 | Mig - | 125 | 4q21 | 14019 | CXCR3 | Xq13 |
| CXCL10 | IP-10 - | 98 | 4q21 | 10856 | CXCR3 | Xq13 |
| CXCL11 | I-TAC - | 94 | 4q21.2 | 10365 | CXCR3 | Xq13 |
| CXCL12 | SDF-1α/β - | 93 | 10q11.1 | 10666 | CXCR4 | 2q21 |
| CXCL13 | BLC, BCA-1 - | 109 | 4q21 | 12664 | CXCR5 | 11 |
| CXCL14 | BRAK - | 99 | 5q31 | 11722 | ? | |
| CX3C Chemokines | ||||||
| CX3CL1 | fractalkine | 397 | 16q13 | 42202 | CX3CR1 | 3p21 |
表格来源:https://www.ncbi.nlm.nih.gov/books/NBK6294/?log$=activity
人趋化因子、受体及效应
| 类别 | 趋化因子 | 来源 | 受体 | 募集的细胞 | 主要效应 |
| CXC | CXCL8 (IL- 8) | 单核细胞 巨噬细胞 成纤维细胞、上皮细胞 内皮细胞 | CXCR1 CXCR2 | 中性粒细胞 初始T细胞 | 中性粒细胞的动员, 激活和脱颗粒化 血管生成 |
| CXCL7 (PBP,β-TG, NAP-2) | 血小板 | CXCR2 | 中性粒细胞 | 激活中性粒细胞 凝块吸收 血管生成 | |
| CXCL1( GROa) CXCL2(GROβ) CXCL3(GROγ) | 单核细胞 成纤维细胞 内皮细胞 | CXCR2 | 中性粒细胞 未成熟T细胞 成纤维细胞 | 激活中性粒细胞 纤维增生 血管生成 | |
| CC | CCL3 (MIP-1α) | 单核细胞 T细胞 肥大细胞 成纤维细胞 | CCR1 CCR3 CCR5 | 单核细胞 NK和T细胞 嗜碱性粒细胞 DC | 与HIV-1竞争 抗病毒防御 促进Th1免疫 |
| CCL4 (MIP-1β) | 单核巨噬细胞 中性粒细胞 内皮细胞 | CCR1 CCR3 CCR5 | 单核细胞 NK和T细胞 DC | 与HIV-1竞争 | |
| CCL2 (MCP -1) | 单核细胞 巨噬细胞 成纤维细胞 角质形成细胞 | CCR2B | 单核细胞 NK和T细胞 嗜碱性粒细胞 DC | 激活巨噬细胞 嗜碱性粒细胞释放 组胺 促进Th2免疫 | |
| CCL5 ( RANTES) | T细胞 内皮细胞 血小板 | CCR1 CCR3 CCR5 | 单核细胞 NK和T细胞 嗜碱性粒细胞 嗜酸性粒细胞 DC | 嗜碱性粒细胞脱颗粒化 激活T细胞 慢性炎症 | |
| CXXXC | CX3CL1 (曲动蛋白) | 单核细胞 内皮细胞 小胶质细胞 | CX₃ CR1 | 单核细胞 T细胞 | 白细胞-内皮黏附 脑炎 |
黏附分子

| 名称 | 组织分布 | 配体 | |
| 选择素 | P选择素 (PADGEM、CD62P) | 活化的内皮细胞 与血小板 | PSGL-1、s-Le× |
| E选择素 (ELAM1、CD62E) | 活化的内皮细胞 | s-Le | |
| 整合素 | aLβ₂ ( LFA-1, CD¹1a:CD18) | 单核细胞,T细胞, 巨噬细胞,中性粒细 胞,DC,NK细胞 | ICAM-1、ICAM-2 |
| am:B₂ (CR3,Mac-1, CD11b:CD18) | 中性粒细胞,单核 细胞,巨噬细胞, NK细胞 | ICAM-1、iC3b、 纤维蛋白原 | |
| ax:B₂ (CR4, p150.95, CD11c:CD18) | DC,巨噬细胞, 中性粒细胞,NK细胞 | iC3b | |
| a₅ ;β₁ (VLA-5, CD49d:CD29) | 单核细胞,巨噬细胞 | 纤连蛋白 | |
| 免疫球蛋白超家族 | ICAM-1(CD54) | 活化的内皮细胞和 活化的白细胞 | LFA-1、Mac1 |
| ICAM-2(CD102) | 静息内皮细胞、DC | LFA-1 | |
| VCAM-1(CD106) | 活化内皮细胞 | VLA-4 | |
| PECAM(CD3 1) | 活化的白细胞和内 皮层细胞间的连接处 | CD31 |

中性粒游走出血管壁过程
免疫学总结
写的比我详细多了(︶.̮︶✽)
https://www.sciencedirect.com/science/chapter/monograph/pii/B9780124200302000184

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